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Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, kill more than 4 million people every year, and affect hundreds of millions more. These diseases erode the health and well-being of the patients and have a negative impact on families and societies. This report raises awareness of the huge impact of chronic respiratory diseases worldwide, and highlights the risk factors as well as ways to prevent and treat these diseases.
Annotation In the western world, the prevalence of allergy and asthma has increased two- to threefold over the last 40 years and has reached epidemic proportions. This book represents the first complete document containing recommendations on the prevention of allergy and allergic asthma based on the current understanding of the immunological mechanisms of allergic reactions. Prevention of Allergy and Allergic Asthma was a collaborative project between the WAO (World Allergy Organization) and the WHO, launched in 1999. Following two interim reports, this monograph is the final report of the group of international experts involved in the project, ranging from basic immunologists to clinicians. Both theoretical and practical aspects are discussed, and constructive advice is given. Through its network of more than 70 member societies, the WAO will now promote the concept of prevention of allergies and allergic asthma worldwide to benefit patients prone to become allergic, to prevent the worsening of existing allergic diseases, and to reduce their high cost to society. This publication is recommended to specialists in allergy, pediatrics, pneumology and dermatology as well as to general practitioners, health care professionals, journalists, politicians and patients. Only by increasing the knowledge about allergic diseases throughout society can the right steps be taken for their effective prevention.
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.
This unique book is a first-of-its-kind resource, comprehensively guiding readers through the epidemiology, pathophysiology, recent diagnostic criteria, and management options for patients with Food Protein-Induced Enterocolitis Syndrome (FPIES). Food-Protein Induced Enterocolitis Syndrome: Diagnosis and Management opens with a historical perspective of this condition, before moving into discussions of epidemiology and pathophysiology. FPIES can be difficult to diagnose as the symptoms overlap with multiple other conditions, and so clear differential diagnosis will be reviewed for both chronic FPIES, as well as acute FPIES. Later chapters are case-based, providing detailed multiple perspectives on the diagnosis and management of FPIES in patients with varying complicating factors and severity. Later chapters will tackle issues of quality of life in patient care, nutritional management for patients, and discussing working with parents and families to improve communication and at-home care. Parents, families and caregivers will also find chapters useful and relatable. A final chapter will look to the future of FPIES, addressing new research, guidelines, and implications for clinicians working with pediatric patients with FPIES, and for their families. Concise and practical, this book will be an ideal reference for allergists, pediatricians, family practice clinicians, gastroenterologists, nutritionists, and all other health care providers who encounter FPIES, and assist them in providing up-to-date, quality care for pediatric patients affected by this condition.
This book offers a handy reference guide to anaphylaxis, including diagnosis and treatment. It covers food, drug allergy and venom allergies, allergic rhinitis and asthma, anaphylaxis related to intravenous drug administration, exercise-induced anaphylaxis, latex allergy, idiopathic anaphylaxis, and also discusses applied treatment modalities that cause anaphylaxis, such as various forms of immunotherapy. Providing detailed information on three recently launched epinephrine auto-injectors, this guide is an invaluable tool for otorhinolaringologists, pediatric and adult allergologists, pulmonologists general practitioners and emergency physicians as well as patients.
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.