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In its 114th year, Billboard remains the world's premier weekly music publication and a diverse digital, events, brand, content and data licensing platform. Billboard publishes the most trusted charts and offers unrivaled reporting about the latest music, video, gaming, media, digital and mobile entertainment issues and trends.
Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.
Globally, there is growing recognition of foodborne diseases as a public health priority. From a public health perspective, foodborne diseases are largely preventable, and can be controlled through effective food safety systems that evaluate hazards along the food chain, from production to consumption. An integrated food chain surveillance system can detect and monitor foodborne bacteria, including antimicrobial resistant bacteria, throughout the food chain. Whole genome sequencing (WGS) has the potential to change how we detect and monitor microbial hazards in the food chain, as well as how we assess, investigate and manage food safety risks. It is anticipated that this new technology will help reduce the burden of foodborne diseases, given its advantages over previous low-resolution typing and detection methods. The purpose of this manual is to provide guidance on: - The capacities that need to be in place before WGS can be useful for foodborne disease surveillance and response; - The options for implementing WGS; and - How to implement WGS within existing surveillance and response systems. This module is about using WGS in routine surveillance of foodborne diseases. It is meant for countries experienced in laboratory-based surveillance of foodborne pathogens. WGS can be implemented where subtyping foodborne pathogens or replacing traditional typing methods is being considered. Routine surveillance includes outbreak detection, monitoring trends over time, and using WGS for AMR and virulence factor monitoring.
Food safety is a global concern, and consumers have the right to safe and nutritious food (FAO, 1996). Considerable efforts to strengthen food control systems have been made in many countries. However, while progress has been made, the estimated global burden of foodborne diseases: 600 million foodborne illnesses and 420 000 deaths from 31 major food safety hazards in 2010 (WHO, 2015)1 and the related social and economic costs (loss of income, employment and market access) remain unacceptably high. In addition, food safety is an important element in achieving food security, which is negatively impacted by both the health and economic aspects of unsafe food. Within this context, there are ongoing efforts in the way in which the building blocks of food control systems are developed and implemented, from legislative aspects to surveillance and monitoring programmes, and the tools used by laboratories. Whole Genome Sequencing (WGS) has recently emerged as a new tool, and offers great potential in the way we investigate, assess and manage microbiological food safety issues and illnesses. It allows the identification and characterization of micro-organisms with a level of precision not previously possible, therefore potentially minimizing much of the uncertainty which impacts our ability to respond and manage microbiological food safety issues effectively and efficiently. This, in addition to its rapidly declining costs, increases the attractiveness of incorporating such a tool in food safety management. While several industrialized countries have been moving forward with the technology, its application is limited, particularly in developing and transitional countries. Information describing the potential benefits, possible drawbacks, infrastructure requirements and technical challenges is urgently needed if countries are to make appropriate decisions about when and where to use this technology to strengthen national food control systems.
The long-awaited first biography of W. G. Sebald 'The best biography I have read in years' Philippe Sands 'Spectacular' Observer 'A remarkable portrait' Guardian W. G. Sebald was one of the most extraordinary and influential writers of the twentieth century. Through books including The Emigrants, Austerlitz and The Rings of Saturn, he pursued an original literary vision that combined fiction, history, autobiography and photography and addressed some of the most profound themes of contemporary literature: the burden of the Holocaust, memory, loss and exile. The first biography to explore his life and work, Speak, Silence pursues the true Sebald through the memories of those who knew him and through the work he left behind. This quest takes Carole Angier from Sebald's birth as a second-generation German at the end of the Second World War, through his rejection of the poisoned inheritance of the Third Reich, to his emigration to England, exploring the choice of isolation and exile that drove his work. It digs deep into a creative mind on the edge, finding profound empathy and paradoxical ruthlessness, saving humour, and an elusive mix of fact and fiction in his life as well as work. The result is a unique, ferociously original portrait.
Microsoft SQL Server implements extensive support for location-based data. Pro Spatial with SQL Server 2012 introduces SQL Server’s spatial feature set, and covers everything you'll need to know to store, manipulate, and analyze information about the physical location of objects in space. You’ll learn about the geography and geometry datatypes, and how to apply them in practical situations involving the spatial relationships of people, places, and things on Earth. Author Alastair Aitchison first introduces you to SQL Server’s spatial feature set and the fundamental concepts involved in working with spatial data, including spatial references and co-ordinate systems. You’ll learn to query, analyze, and interpret spatial data using tools such as Bing Maps and SQL Server Reporting Services. Throughout, you'll find helpful code examples that you can adopt and extend as a basis for your own projects. Explains spatial concepts from the ground up—no prior knowledge is necessary Provides comprehensive guidance for every stage of working with spatial data, from importing through cleansing and storing, to querying, and finally for retrieval and display of spatial data in an application layer Brilliantly illustrated with code examples that run in SQL Server 2012, that you can adapt and use as the basis for your own projects.
The German novelist, poet and critic W. G. Sebald (1944-2001) has in recent years attracted a phenomenal international following for his evocative prose works such as Die Ausgewanderten (The Emigrants), Die Ringe des Saturn (The Rings of Saturn) and Austerlitz, spellbinding elegiac narratives which, through their deliberate blurring of genre boundaries and provocative use of photography, explore questions of Heimat and exile, memory and loss, history and natural history, art and nature. Saturn's Moons: a W. G. Sebald Handbook brings together in one volume a wealth of new critical and visual material on Sebald's life and works, covering the many facets and phases of his literary and academic careers -- as teacher, as scholar and critic, as colleague and as collaborator on translation. Lavishly illustrated, the Handbook also contains a number of rediscovered short pieces by W. G. Sebald, hitherto unpublished interviews, a catalogue of his library, and selected poems and tributes, as well as extensive primary and secondary bibliographies, details of audiovisual material and interviews, and a chronology of life and works. Drawing on a range of original sources from Sebald's Nachlass - the most important part of which is now held in the Deutsches Literaturarchiv Marbach - Saturn's Moons6g will be an invaluable sourcebook for future Sebald studies in English and German alike, complementing and augmenting recent critical works on subjects such as history, memory, modernity, reader response and the visual. The contributors include Mark Anderson, Anthea Bell, Ulrich von Buelow, Jo Catling, Michael Hulse, Florian Radvan, Uwe Schuette, Clive Scott, Richard Sheppard, Gordon Turner, Stephen Watts and Luke Williams. Jo Catling teaches in the School of Literature at the University of East Anglia and Richard Hibbitt in the Department of French at the University of Leeds.
This book covers the entire field of satellite geodesy and is intended to serve as a textbook for advanced undergraduate and graduate students, as well as a reference for professionals and scientists in the fields of engineering and geosciences such as geodesy, surveying engineering, geomatics, geography, navigation, geophysics and oceanography. The text provides a systematic overview of fundamentals including reference systems, time, signal propagation and satellite orbits, together with observation methods such as satellite laser ranging, satellite altimetry, gravity field missions, very long baseline interferometry, Doppler techniques, and Global Navigation Satellite Systems (GNSS). Particular emphasis is given to positioning techniques, such as the NAVSTAR Global Positioning System (GPS), and to applications. Numerous examples are included which refer to recent results in the fields of global and regional control networks; gravity field modeling; Earth rotation and global reference frames; crustal motion monitoring; cadastral and engineering surveying; geoinformation systems; land, air, and marine navigation; marine and glacial geodesy; and photogrammetry and remote sensing. This book will be an indispensable source of information for all concerned with satellite geodesy and its applications, in particular for spatial referencing, geoinformation, navigation, geodynamics, and operational positioning.
The first conclusive, empirical demonstration of the utility of research on governance.