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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. - Provides detailed mathematical model development to interpret experiments and provides current modeling practices - Provides a wide range of biological and clinical applications - Includes physiological descriptions of models
Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.
All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are seen differently by biologists, chemists, or physicists. Biologists concentrate their attention on cell structure and function. What the cells consists of? Where are its organelles? What function each organelle fulfils? From a chemists’ point of view, a cell is a complex chemical reaction chamber where various molecules are synthesized or degraded. The main question is how these, sometimes very complicated chains of reactions are controlled. Finally, from a physics standpoint, some of the fundamental questions are about the physical movement of all these molecules between organelles within the cell, their exchange with the extracellular medium, as well as electrical phenomena resulting from such transport. The aim of this book is to look into the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and various electrical effects, and that in turn leads to biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goals of every cell are to stay alive and to fulfill its function as a part of a larger organ or organism. The first volume of this book is an inventory of physical transport processes occurring in cells while this second volume provides a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.
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Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
The lipid bilayer is the most basic structural element of cell membranes. A wide range of topics are covered in this volume, from the origin of the lipid bilayer concept, to current applications and experimental techniques. Each chapter in this volume is self-contained and describes a group's research, providing detailed methodology and key references useful for researchers. Lipid bilayer research is of great interest to many because of it's interdisciplinary nature.·Provides an overview of decades of research on the lipid bilayer·38 contributed chapters, by leading scientists, cover a wide range of topics in one authoritative volume·Book coincides with 40th anniversary of BLM
As plant physiology increased steadily in the latter half of the 19th century, problems of absorption and transport of water and of mineral nutrients and problems of the passage of metabolites from one cell to another were investigated, especially in Germany. JUSTUS VON LIEBIG, who was born in Darmstadt in 1803, founded agricultural chemistry and developed the techniques of mineral nutrition in agricul ture during the 70 years of his life. The discovery of plasmolysis by NAGEL! (1851), the investigation of permeability problems of artificial membranes by TRAUBE (1867) and the classical work on osmosis by PFEFFER (1877) laid the foundations for our understanding of soluble substances and osmosis in cell growth and cell mechanisms. Since living membranes were responsible for controlling both water movement and the substances in solution, "permeability" became a major topic for investigation and speculation. The problems then discussed under that heading included passive permeation by diffusion, Donnan equilibrium adjustments, active transport processes and antagonism between ions. In that era, when organelle isolation by differential centrifugation was unknown and the electron microscope had not been invented, the number of cell membranes, their thickness and their composition, were matters for conjecture. The nature of cell surface membranes was deduced with remarkable accuracy from the reactions of cells to substances in solution. In 1895, OVERTON, in U. S. A. , published the hypothesis that membranes were probably lipid in nature because of the greater penetration by substances with higher fat solubility.