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Inspired by John Cheever's classic short story, 'The Swimmer', Roger Deakin set out from his home in Suffolk to swim through the British Isles. The result of his journey is this personal view of an island race.
A Mother Jones' Best Book of the Year "A beautiful ode to the act of swimming outdoors. . . . Deakin’s insistence on wild swimming for all is really an insistence on a better ecosystem for all." —The Atlantic A masterpiece of nature writing, Roger Deakin’s Waterlog is a fascinating and inspiring journey into the aquatic world that surrounds us. In an attempt to discover his island nation from a new perspective, Roger Deakin embarks from his home in Suffolk to swim Britain—the seas, rivers, lakes, ponds, pools, streams, lochs, moats, and quarries. Through the watery capillary network that braids itself throughout the country, Deakin immerses himself in the natural habitats of fish, amphibians, mammals, and birds. And as he navigates towns, private property, and sometimes dangerous waters and inclement weather, Deakin finds himself in precarious situations: he’s detained by bailiffs in Winchester, intercepted by the coast guard at the mouth of a river, and mistaken for a dead body on a beach. The result of this surprising journey is a deep dive into modern Britain, especially its wild places. With enchanting descriptions of natural landscapes, and a deep well of humanity, boundless humor, and unbridled joy, Deakin beckons us to wilder waters and inspires us to connect to the larger world in a most unexpected way. Thrilling, vivid, and lyrical, Waterlog is a fully immersive adventure—a remarkable personal quest, a bold assertion of the swimmer’s right to roam, and an unforgettable celebration of the magic of water.
Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules: Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars. Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.
This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.