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Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was touted as a pathbreaking therapy to treat heart failure in black patients. Kahn reveals that, at the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked. He examines the legal and calls for a more reasoned approach to using race in biomedical research and practice.
This work is devoted to a study fo Roman logistics from the Punic Wars through the Principate. It explores various aspects of supply: rations, trains, foraging, supply lines; administration and logistics in warfare. The book traces the increasing sophistication of the Roman military supply system.
This series of intimate and penetrating portraits of male addicts provides a unique window onto how men relate to drugs and alcohol--and why so many are drawn to these substances. Poignant and deeply moving, "Message in a Bottle" brings readers to a fuller understanding of these men and the world in which they live.
Ten Green Bottles is the story of Nini Karpel's struggles as she told it to her daughter Vivian Jeanette Kaplan so many years ago. This true story depicts the fierce perseverance of one family, victims of the forces of evil, who overcame suffering of biblical proportion to survive. It was a time when ordinary people became heroes. To Nini Karpel, growing up in Vienna during the 1920s was a romantic confection. Whether schussing down ski slopes or speaking of politics in coffee houses, she cherished the city of her birth. But in the 1930s an undercurrent of conflict and hate began to seize the former imperial capital. This struggle came to a head when Hitler took possession of neighboring Germany. Anti-Semitism, which Nini and her idealistic friends believed was impossible in the socially advanced world of Vienna, became widespread and virulent. The Karpel's Jewish identity suddenly made them foreigners in their own homeland. Tormented, disenfranchised, and with a broken heart, Nini and her family sought refuge in a land seven thousand miles across the world. Shanghai, China, one of the few countries accepting Jewish immigrants, became their new home and refuge. Stepping off the boat, the Karpel family found themselves in a land they could never have imagined. Shanghai presented an incongruent world of immense wealth and privilege for some and poverty for the masses, with opium dens and decadent clubs as well as rampant disease and a raging war between nations.
The contour Coca-Cola bottle is the most recognized package created by man. It has been called an international icon and one of the most significant artifacts of the twentieth century. Of everything that has been written about The Coca-Cola Company, the one error of omission has been the complete and accurate story about the creation of its famous contour bottle and the impact it has made in the world. Knowing his entire life that it was his father, Earl R. Dean, who designed the bottle, it became the author's mission to get the story told before the truth was forever lost-to set the record straight-not only for his father and his descendants, but for the millions of people all over the world who have enjoyed a romance with his bottle.
Chronicles the last half century's haphazard attempt to harness fusion energy, describing how governments and research teams throughout the world have employed measures ranging from the controversial to the humorous.
A family finds a mysterious bottle. Within the bottle, a book. Within the book, a story. And within the story their own adventure. Supposing a book were to appear sewn from all the different parts of your favorite stories. What could it be, but a tale of change? .Frogs become princes, orphans become kings, kings become beggars, milkmaids become knights. Duels become dances, tombs become houses, a deathly chase becomes a coronation. We read to children bedtime stories that warn them and promise them: all thing change. Then we click off the light, expecting them to be unchanged when they wake in the morning. In a bottle is a book, and in the book is a city built of pieces. In that city is a beggar who became a duke, a rat who becomes a cat, a song that became a promise. Ghosts, assassins, kings and cobblers shift and dance across this city, finding who they are by what story they tell of themselves. And in the very center of the dance, a man stands balanced on a wheel.From the book: I consider. "A good adventure story has a chase through a graveyard. There shall be a duel on a cliff by moonlight or firelight or lightning. There must be treasure. A magic ring. A haunted tomb and a ruined castle. Guards tricked, villains confounded. A lost heir, disguises, an assassin, ghosts, revenge, mutant tigers -" "What?" I ignore that. "- mutant tigers, an ancient battle between good and evil, an execution, a daring escape. There must be a prophecy that actually surprises, a final battle with an unexpected ending. There must be dull villagers, street-smart orphans and an impossibly clever-but-wicked noble villain." "What book is this?" I brush that aside. "No one book. It is my list of pieces from the best. Adventures by night in a graveyard are in Tom Sawyer, in Great Expectations, The Horse and His Boy, in Harry Potter. Duels are in The Three Musketeers and The Princess Bride. The Westing Game and The Three Musketeers have mystery and disguises. The Treasure of Alpheus Winterborn and The Hobbit and Treasure Island and Tom Sawyer have treasures and a mystery. The High King and The Mouse and His Child have a prophecy that actually surprises. Lord of The Rings has magic rings and ghosts and the lost heir and mutant tigers -" "Does not!" " -and The Beggar Princess and The Prince and The Pauper have the clever street-wise kids. Harry Potter and The Black Cauldron and The Sword in the Stone and Momo and The Wizard of Oz all have the crazy wizard and the orphan with a destiny and The Last Unicorn and Lud in the Mist and The Thirteen Clocks and Three Musketeers and The Princess Bride have the sly noble villain."I have to stop for breath. I must be getting old.
When friends Marwa and Ahmad detonate an unexploded cluster bomb that they think is a little yellow bottle, they must learn to live with the injuries they receive with the help of a friendly man who had suffered the same fate.
A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science Friday With a new postscript by the author From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticals Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.