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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. - Covers viral assembly using heterologous expression systems and cell extracts - Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment - Includes information on structural studies on antibody/virus complexes
Designed as an upper-level textbook and a reference for researchers, this important book concentrates on central concepts of the bacterial lifestyle. Taking a refreshingly new approach, it present an integrated view of the prokaryotic cell as an organism and as a member of an interacting population. Beginning with a description of cellular structures, the text proceeds through metabolic pathways and metabolic reactions to the genes and regulatory mechanisms. At a higher level of complexity, a discussion of cell differentiation processes is followed by a description of the diversity of prokaryotes and their role in the biosphere. A closing section deals with man and microbes (ie, applied microbiology). The first text to adopt an integrated view of the prokaryotic cell as an organism and as a member of a population. Vividly illustrates the diversity of the prokaryotic world - nearly all the metabolic diversity in living organisms is found in microbes. New developments in applied microbiology highlighted. Extensive linking between related topics allows easy navigation through the book. Essential definitions and conclusions highlighted. Supplementary information in boxes.
This book is the first to explore the distribution, fate, and ecology of phage in the environment and point up the important applications of this information. The text begins with an historical overview, followed by a discussion of the current state of phage taxonomy. Next is covered the distribution patterns and fate of phage in diverse environments, e.g. soil, fresh water, marine water, and water and wastewater treatment plants. Factors that can influence the numbers and activity of phage populations, e.g. host and phage density, association of a phage with solids, presence of organic matter, temperature, pH, ultraviolet and visible light, concentration and types of ions present, and the metabolic activities of bacteria other than the phage host are examined. One chapter is devoted to the occurrence and implications of phage in various industries, e.g. dairy, wine, sausage, and antibiotic industries.
Viruses, Bacteria and Fungi in the Built Environment: Designing Healthy Indoor Environments opens with a brief introduction to viruses, bacteria and fungi in the built environment and discusses their impact on human health. Sections discuss the microbiology of building materials, the airborne transmission of viruses and bacteria in the built environment, and plumbing-associated microbiome. As the first book on this important area to be written in light of the COVID-19 pandemic, this work will be a valuable reference resource for researchers, civil engineers, architects, postgraduate students, contractors and other professionals working and interested in the field of the built environment. Elements of building design, including choice of materials, ventilation and plumbing can have important implications for the microbiology of a building, and consequently, the health of the building's occupants. This important new reference work explains the microbiology of buildings and disease control in the built environment to those who design and implement new construction and renovate. - Provides an essential guide on the microbiology of buildings, covering bacteria, fungi and viruses on surfaces, in air and in water - Comprehensively examines how humidity influences fungal growth in several building materials - Includes important information about the airborne transmission of infectious agents - Addresses ventilation design to improve human health - Presents the first book on disease control in buildings since the COVID-19 pandemic
Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived 'interactomics' as defined by the molecules and the processes by which virus gene products interact with themselves and their host's cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses - Provides key insights into recent technological advances, including high-throughput sequencing - Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life - Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.