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Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.
Nanobiotechnology: Microbes and Plant Assisted Synthesis of Nanoparticles, Mechanisms and Applications covers in detail the green synthesis of nanostructures of tailor-made size, shape and physico-chemical and opto-electronic properties. The rationale behind the selection of bacteria, cyanobacteria, algae, fungi, virus and medicinal plants for the synthesis of biologically active exotic nanoparticles for biomedical applications is also part of this book. It also explores metal recovery, bioconversion, detoxification and removal of heavy metals using nanobiotechnology and discusses the potential of nanobiotechnology to address environmental pollution and toxicity. The book further covers the economic and commercial aspects of such green nanobiotechnology initiatives, its current status in intellectual property rights like patents filed so far globally, technology transfers, and market potential. This information enables one to decipher the scope of biogenic nanoparticles and its prospects. - Provides an overview on the general and applied aspects on nanotechnology - Gives the scope of exploring bacteria, fungi, algae, virus and medicinal plants for the synthesis of exotic nanoparticles - Furnishes a comprehensive report on the underlying molecular mechanisms behind the biosynthesis of nanoparticles - Outlines sustainable alternative strategies of bioremediation of heavy metals, metal recovery, detoxification and bioconversion using nanobiotechnology - Explores the promises of patenting, technology transfer and commercialization potential of biogenic nanoparticles
This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Detection and Analysis of SARS Coronavirus Detecting and analyzing the COVID-19 pandemic with biosensor technology The highly contagious SARS CoV-2 pathogen has challenged health systems around the world as they struggle to detect and monitor the spread of the pathogen. In Detection and Analysis of SARS Coronavirus: Advanced Biosensors for Pandemic Viruses and Related Pathogens expert chemists Chaudhery Mustansar Hussain and Sudheesh K. Shukla deliver a practical analysis of how contactless coronavirus detectors may be developed using existing biosensor technology. The editors outline current challenges in the field, the bioanalytical principles for coronavirus detection, and available biosensor technology. They then move on to how available technology might be adapted to detect coronaviruses and how commercialization of the technology might unfold. The lessons learned in this book are readily applicable to the study of other current and emerging pathogens. Readers will also enjoy: A thorough introduction to the current diagnostic approaches for COVID-19, including common challenges, technology adaptation, and future potential An exploration of bio-analytical strategies for SARS CoV-2/COVID-19, including COVID detection via nanotechnology, biosensing approaches, and the role of nanotechnology in coronavirus detection Practical discussions of biosensors for the analysis of SARS CoV-2/COVID-19, including sensor development for coronavirus and chemical sensors for coronavirus diagnosis In-depth treatments of the commercialization and standardization for analytical technologies Perfect for virologists, pharmaceutical industry professionals, and sensor developers, Detection and Analysis of SARS Coronavirus is also an indispensable resource for those working in analytical research institutes, biotechnology industry professionals, and public health agency professionals.
Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.
Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases delivers comprehensive coverage of the application of nanotechnology to pressing problems in infectious disease. This text equips readers with cutting-edge knowledge of promising developments and future prospects in nanotechnology, paying special attention to microbes that are now resistant to conventional antibiotics, a concerning problem in modern medicine. Readers will find a thorough discussion of this new approach to infectious disease treatment, including the reasons nanotechnology presents a promising avenue for the diagnosis, treatment, and prophylaxis of infectious diseases. - Provides a comprehensive overview of the use of nanotechnology in the treatment and diagnosis of infectious diseases - Covers all common types of infective agents, including bacteria, viruses, fungi, and protozoa, along with their vectors, ticks, mosquitoes, flies, etc. - Delivers commentary from an international researcher base, providing insights across differing economic statuses - Includes a foundation of basic nanotechnological concepts to aid in designing new strategies to combat several pathogenic diseases and cancer - Illustrates the high antimicrobial potential of nanoparticles, ultimately demonstrating how they are a promising alternative class that can be successfully used in fighting a myriad of infections
In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.
Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. - Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions - Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena - Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes
Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.
Nanotechnology and Nanomaterials in the Treatment of Life-threatening Diseases takes a scientific approach to nanotechnology and nanomaterials applications in medicine, while also explaining the core biological principles for an audience of biomedical engineers, materials scientists, pharmacologists, and medical diagnostic technicians. The book is structured by major disease groups, offering a practical, application-based focus for scientists, engineers, and clinicians alike. The spectrum of medical applications is explored, from diagnostics and imaging to drug delivery, monitoring, therapies, and disease prevention. It also focuses specifically on the synthesis of nanomaterials and their potential health risks (particularly toxicity). Nanomedicine — the application of nanomaterials and devices for addressing medical problems — has demonstrated great potential for enabling improved diagnosis, treatment, and monitoring of many serious illnesses, including cancer, cardiovascular and neurological disorders, HIV/AIDS, and diabetes, as well as many types of inflammatory and infectious diseases. - Gain an understanding of how nanotechnologies and nanomaterials can be deployed in the fight against the major life-threatening diseases: cancer, neurological disorders (including Alzheimer's and Parkinson's), cardiovascular diseases, and HIV/AIDS - Discover the latest developments in nanomedicine, from therapies and drug delivery to diagnostics and disease prevention - The authors cover the health risks of nanomaterials as well as their benefits, considering toxicity and potential carcinogens