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An international group of leading investigators discuss recent progress of sensory structures in lower and higher vertebrates. Experts in two relevant fields--the cell cycle and mitogenic growth factors--present insightful contributions in the search for precursors and/or stem cells in each sense organ plus the signals which regulate those precursors' differentiation both in normal development and regeneration.
This is the first book that analyses the mechanisms of limb regeneration by incorporating the information obtained from older experiments with the many new recent advances in molecular and cellular biology.
The regenerating vertebrate limb is an excellent model for exploring a number of significant questions in developmental biology. Written by leading investigators in the field, this collection provides a comprehensive discussion of the roles played by the major regulators affecting limb regeneration and repair following trauma. Using the amphibian limb as the recognized model system, the contributors explore in detail the contributions made by biopotentials, the skin, the endocrine system, and nerves in regulating such events as dedifferentiation, the proliferation of blastema cells , and pattern formation. The modulating roles of blood cells and the immune system are re-examined, and the exciting studies on the isolation and characterization of neurotropic factors reviewed. The sometimes provocative but always informative and up-to-date discussions provided in this volume will be of particular interest to developmental biologists, anatomists, neuroscientists, and cell biologists.
The present review covers a very neglected field in regeneration studies, namely, tissue and organ regeneration in reptiles, especially represented by the lizard model of regeneration. The term “regeneration” is intended here as “the ability of an adult organism to recover damaged or completely lost body parts or organs.” The process of recovery is further termed “restitutive regeneration” when the lost part is reformed and capable of performing the complete or partial physiological activity performed by the original, lost body part. Lizards represent the only amniotes that at the same time show successful organ regeneration, in the tail, and organ failure, in the limb (Marcucci 1930a, b; Simpson 1961, 1970, 1983). This condition offers a unique opportunity to study at the same time mechanisms that in different regions of the same animal control the success or failure of regeneration. The lizard model is usually neglected in the literature despite the fact that the lizard is an amniote with a basic histological structure similar to that of mammals, and it is therefore a better model than the salamander (an a- mniote) model to investigate regeneration issues.
This Open Access volume provides a comprehensive overview of the latest tools available to scientists to study the many facets of whole-body regeneration (WBR). The chapters in this book are organized into six parts. Part One provides a historical overview on the study of the WBR phenomena focusing on the primary challenges of this research. Parts Two and Three explore a series of non-vertebrate zoological contexts that provide experimental models for WBR, showing how they can be approached with cellular tools. Parts Four, Five, and Six discuss the future advancements of WBR, reporting about the cutting-edge techniques in genetics and omics used to dissect the underlying mechanisms of WBR, and systems biology approaches to reach a synthetic view of WBR. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Whole-Body Regeneration: Methods and Protocols is a valuable resource for scientists and researchers who want to learn more about this important and developing field.