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Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume I present a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the physiological analysis of the nucleus; nuclear matrix, interchromatin, and perichromatin granules; structure and function of centrioles; characteristics of mitochondria; Golgi complex in cell differentiation and neoplasia; and degranulation of rough endoplasmic reticulum. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, scientists, students, and researchers.
Ultrastructural Pathology
Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume 2 presents a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the structure, distribution, and variations of rod-shaped microtubulated bodies; morphology of intracytoplasmic filaments; melanosome-producing and melanosome-containing cells in tumours; myofilaments in striated muscle; and pathological variations in size, shape, and numbers of microbodies. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, pathologists, students, and researchers.
Diagnostic Ultrastructural Pathology, Volume III, presents individual problem-based cases in a well-illustrated format, using numerous electron micrographs to convey appropriate and necessary visual information for the diagnosis of human disease. The format facilitates the teaching of the case approach for diagnostic ultrastructural pathology using clinical-ultrastructural-pathologic correlation. These guides illustrate key reasoning processes that physicians use to resolve individual clinical problems through the use of electron microscopy. The material is useful to a wide variety of physicians and students of medicine, structure, and disease at various levels of training, as well as in the training of and operational use by technical support staff. The two volumes include a total of 50 cases and a procedural guide for the ultrastructural pathology laboratory. The cases were selected using four principal criteria: (1) classic cases, which are diagnosed readily by light microscopy to facilitate the electron microscopic diagnosis of less classic cases; (2) diagnostic cases, for which ultrastructural analysis is essential for diagnosis; (3) supportive cases, where either the light or the electron microscopic diagnosis is supportive, and thus confirmatory, of the other; and (4) new facts cases, which establish new knowledge regarding the pathogenesis of disease using electron microscopy as the investigative modality. The 50 cases are grouped anatomically in four major categories. Volume III presents the cases dealing with the endocrine and hematopoietic systems. Each section is preceded by introductory remarks. Each case cites relevant, classic, anatomic pathology papers and related research papers. These volumes also include multiple functional indices, providing ready access to the material from several starting points. There are separate indices for presenting symptoms, differential diagnostic groups, ultrastructural pathology criteria, and final diagnostic categories. As a valuable resource and guide, Diagnostic Ultrastructural Pathology Volume III, is an excellent, high-quality addition to the field of diagnostic pathology.
The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
Describes the use of immunohistochemistry and electron microscopy in the diagnosis of undifferentiated tumors.