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Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.
Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
The Test Drive deals with the war perpetrated by highly determined reactionary forces on science and research. How does the government at once promote and prohibit scientific testing and undercut the importance of experimentation? To what extent is testing at the forefront of theoretical and practical concerns today? Addressed to those who are left stranded by speculative thinking and unhinged by cognitive discourse, The Test Drive points to a toxic residue of uninterrogated questions raised by Nietzsche, Husserl and Derrida. Ranging from the scientific probe to modalities of testing that include the limits of friendship or love, this work explores the crucial operations of an uncontestable legitimating machine. Avital Ronell offers a tour-de-force reading of legal, pharmaceutical, artistic, scientific, Zen, and historical grids that depend upon different types of testability, involving among other issues what it means to put oneself to the test.
Dr. John E. Sarno's groundbreaking research on TMS (Tension Myoneural Syndrome) reveals how stress and other psychological factors can cause back pain-and how you can be pain free without drugs, exercise, or surgery. Dr. Sarno's program has helped thousands of patients find relief from chronic back conditions. In this New York Times bestseller, Dr. Sarno teaches you how to identify stress and other psychological factors that cause back pain and demonstrates how to heal yourself--without drugs, surgery or exercise. Find out: Why self-motivated and successful people are prone to Tension Myoneural Syndrome (TMS) How anxiety and repressed anger trigger muscle spasms How people condition themselves to accept back pain as inevitable With case histories and the results of in-depth mind-body research, Dr. Sarno reveals how you can recognize the emotional roots of your TMS and sever the connections between mental and physical pain...and start recovering from back pain today.
This book reviews the research pertaining to nutrient requirements for working in cold or in high-altitude environments and states recommendations regarding the application of this information to military operational rations. It addresses whether, aside from increased energy demands, cold or high-altitude environments elicit an increased demand or requirement for specific nutrients, and whether performance in cold or high-altitude environments can be enhanced by the provision of increased amounts of specific nutrients.
Not all mysteries involve murder ... Funeral Director Jennifer Spencer's walk along the Niagara Parkway on a rainy, cold day leads her to Winter, a distraught young woman who isn't speaking. Travis, the temporary director hired when Uncle Bill passed, is still out for revenge. That won't happen if she listens to the police officers assigned to protect her … but she doesn't. Can Jennifer survive her own harrowing ordeal in order to help Winter get her life back? Book 2 of The Spencer Funeral Home Niagara Cozy Mystery Series
Minerals are, in many ways, the unheralded and often forgotten heroes of keeping our bodies functioning at their best. While the nutrients carbohydrates, proteins and fat may be better well known, minerals are equally vital for helping us get and stay healthy. They play a key role in combatting disease, helping your body heal, managing ongoing chronic health problems such as high blood pressure, minimizing the impact of such common maladies as headaches and PMS, helping children grow up strong, enhancing mental performance at all ages, and fatigue. They truly are your secret weapon for getting and staying your healthiest.In this easy-to-read and easy-to-use guide, pH Lab's team of recognized medical doctors and specialists tell you about the role minerals play with common health issues along with detailed information about individual minerals. You'll also learn more about the relationship between minerals and prescription medicines, why you need more than routine blood tests to see what minerals your body may need, and where you can get these tests.Enjoy your healthy life!
When city girl Morgan Williams arrived in Seaside, Maine, on Christmas Eve, to claim the cottage she'd inherited, she came face-to-face with the handsomest man she'd ever seen. But looks weren't the only thing that Grant Kincaid had to offer. And when he enlisted Morgan's help to raise money for Good Shepherd Camp for troubled kids, she realized there were more important things in life than expensive cars and fancy clothes. Soon Morgan was yearning for a different life...one that included faith and a strong, steadfast Grant by her side.
Organizational Behaviour As A Management Discipline Is A Fascinating Subject And Is Becoming Increasingly Important As People With Diverse Backgrounds And Cultural Values Have To Work Together Effectively And Efficiently. This Book Addresses All The Issues That Come In To Play In An Organization In Today S Global Economy. It Has A Novel Orientation And Its Primary Aim Is To Let Practitioners And Students Know The Latest And Best Trends In Organizational Behaviour. This Book Prescribes Methods To Manage Employees And Suggests That The Management Takes Responsibility For Everything That Might Adversely Affect An Employee S Capacity To Work Creatively And Intelligently, Irrespective Of The Place Inside The Organization Or Outside It. The Focus Of The Book Is On Holistic Development Of The Individual. Peeping Into The Human Mind, It Shows How Organizations Can Tap The Passions And Fears Of Their Employees To Make Them More Creative And Productive. The Book Prescribes A Democratic And Inclusive Management Stye. A Special Feature Of This Book Is That There Is An Innovative Integration Of Chapter Objectives And Summaries Leading To Analysis Through Caselets. Every Point In The Objectives Has Corresponding Text And Is Supplemented By A Case. Going Through This Book Will Be A Personally Fulfilling Experience And Maybe It Succeeds To Make The Readers Better Human Beings, Better Teachers, Better Friends And May Be Even Better Managers.