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A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.
This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.
Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. - Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field - Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients - Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
The purpose of this book is to examine immune-to-brain communication from the viewpoint of its effect on pain processing, and to clarify the major role that substances released by immune cells play in pain modulation. In these chapters, contributed by major laboratories whose focus is understanding how cytokines modulate pain, the perspectives examined range from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans. -- book cover.
Leading authorities on high-altitude physiology contribute to this work, which is divided into three sections: Man at Extreme Altitude; Sleep and Restoration at High Altitude; and Physiology of Permanent Residents of High Altitude. Based on a symposium on physiology at high altitude sponsored by the American Physiological Society, the volume includes several chapters on the achievements of the 1981 American Medical Research Expedition to Mt. Everest, where the first physiological measurements at altitudes above 8,000 meters were recorded. With growing interest in the study of human performance in these conditions, this text marks a lasting achievement in high-altitude physiology.
This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.
Biotechnology and Pharmacy offers a unique overview of the principles of biotechnology and their applications in the pharmaceutical sciences. The book assumes a basic knowledge of biology and chemistry and was written as a text suitable for students of pharmacy or other health sciences. The first part of the book describes the basic elements of biotechnology, such as recombinant DNA and monoclonal antibody technology; the second part comprehensively covers applications of biotechnology in the diagnosis and treatment of disease; and the final part offers a practical discussion of how biotechnology products will affect the practice of pharmacy. Microbiologists, biochemists, and medicinal chemists will also find this book to be a valuable reference.
Handbook of Behavioral State Control: Cellular and Molecular Mechanisms provides the first synthesis of information on the neurobiology of behavioral states, ranging from normal stress and sleep deprivation to debilitating neuropsychiatric disorders. This book presents a working reference on the cellular and molecular mechanisms generating arousal states; pharmacological and non-pharmacological methods of behavioral state control; and the bi-directional interaction between arousal state and the neurobiology of pain, and between sleep and the immune system.