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What are the aims of a criminal trial? What social functions should it perform? And how is the trial as a political institution linked to other institutions in a democratic polity? What follows if we understand a criminal trial as calling a defendant to answer to a charge of criminal wrongdoing and, if he is judged to be responsible for such wrongdoing, to account for his conduct? A normative theory of the trial, an account of what trials ought to be and of what ends they should serve, must take these central aspects of the trial seriously; but they raise a number of difficult questions. They suggest that the trial should be seen as a communicative process: but what kinds of communication should it involve? What kind of political theory does a communicative conception of the trial require? Can trials ever actually amount to more than the imposition of state power on the defendant? What political role might trials play in conflicts that must deal not simply with issues of individual responsibility but with broader collective wrongs, including wrongs perpetrated by, or in the name of, the state? These are the issues addressed by the essays in this volume. The third volume in this series, in which the four editors of this volume develop their own normative account, will be published in 2007.
Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: • Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems • Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index • Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials
Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives. The second volume covers the following topics: - A review of recent patents and natural products in clinical trials to treat schistosomiasis - Natural products: the new intervention regimen for metabolic disorders - Fluorine-containing drugs and drug candidates derived from natural products - Natural products for the management of cardiovascular diseases - Implication of natural compounds for the prevention of ocular diseases.
"The powerful wizard Shazam has been destroyed and his vast responsibility for presiding over the realm of all magic has been shifted to his mightiest champion, Billy Batson. Such a job can only be performed from the Rock of Eternity -- thus, earth is without a defender to balance the worlds of magic and humanity, for the first time in centuries. Freddy Freeman wants to be that protector, but that is an honor that must be earned. Powerless, Freddy must embark on a quest to prove to the Gods that he is worthy to weld the power of Shazam"--Page 4 of cover
Petrodor is a city of alleys and shadows, where life is cheap and the only respected currency is blood. Sasha, the wilful yet talented heroine of Sasha, returns to battle in Joel Shepherd's stunning second volume of A Trial of Blood & Steel.Away from the hills of her Lenayin homeland, she is fighting a new battle in the dark alleys and wealthy houses of Petrodor. An influential trading centre, Petrodor holds the key to preventing the coming war between Lenayin and the mighty Bacosh. Together with her mentor Kessligh, Sasha attempts to navigate the political intrigues of the port city and find a way to stop the war.It is the serrin, the beautiful but dangerous people from beyond the Bacosh, who will be the pivot in this struggle. How much can Sasha trust her old serrin friend Errollyn? And how much can she trust herself?
The period 1792-94 witnessed the emergence of the first genuinely popular radical movement in Britain. After the phenomenal success of Thomas Paine's "Rights of Man", the government moved swiftly to prevent French republican ideas taking hold in Britain, beginning with the prosecution of Paine himself in absentia. This book focuses on this period.
The period 1792-94 witnessed the emergence of the first genuinely popular radical movement in Britain. After the phenomenal success of Thomas Paine's "Rights of Man", the government moved swiftly to prevent French republican ideas taking hold in Britain, beginning with the prosecution of Paine himself in absentia. This book focuses on this period.
In the second volume of his celebrated history of the Hundred Years War, Jonathan Sumption examines the middle years of the fourteenth century and the succession of crises that threatened French affairs of state, including defeat at Poitiers and the capture of the king.
Brian Michael Bendis and Ryan Sook’s reinvention of the future’s greatest super-team continues! The United Planets is less than thrilled with the decision to bring Superboy a thousand years into the future to protect the past. Planet Gotham is under siege. Ultra Boy’s homeworld is on the verge of all-out war. And as if that weren’t enough, new Legionnaire drama unfolds as Saturn Girl and Cosmic Boy throw down over who should take on the Legion’s leadership! Plus, Brainiac 5 will reveal a secret that will make one Legionnaire quit the team-and we ask the burning question: Who is the strongest Legionnaire? And in an event fit for the 31st century, 41 of comics’ greatest artists join the series, with each page of the story starring a different Legionnaire! Plus, an enemy from the past surfaces in the far future, and romance blooms between Superboy and Saturn Girl! Collects Legion of Super-Heroes #7-12.