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Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.
Liver cirrhosis represents one of the major challenges for most physicians and surgeons on a global scale. This book provides practicing hepatologists, gastroenterologists and liver surgeons with a valuable tool in their efforts to understand the (molecular) mechanisms involved, be updated regarding the newest and less invasive diagnostic methods, and educate themselves about the challenges involved in the management of liver cirrhosis and its complications. The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of liver cirrhosis, giving us a well-rounded overview.
About 2 million deaths worldwide annually are attributable to liver diseases. Among them, half die from cirrhosis and the other half from viral hepatitis and hepatocellular carcinoma. When patients with liver cirrhosis develop to the decompensated stage, a variety of complications will occur, such as ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, and jaundice, which will seriously affect the patient's quality of life with reduced survival time and increased socioeconomic burden. Therefore, early assessment and clinical management of cirrhosis and its complications are crucial for both clinicians and patients.
The term "ascites" is from the Greek word askites meaning "baglike." Although most commonly due to cirrhosis, severe liver disease or metastatic cancer, its presence can be a sign of other significant medical problems, such as Budd-Chiari syndrome. Diagnosis of the cause is usually done with blood tests, an ultrasound scan of the abdomen, and direct removal of the fluid by a needle or paracentesis (which may also be therapeutic). Treatment using medications (diuretics), external drainage, or other treatments is clearly defined. In this book, the authors describe the physiopathology of the diverse causes of ascites,the types of treatments recommended, the recent advances achieved, the complications and the prognosis of the different clinical situations that doctors must face.
Liver cirrhosis, the final stage of various chronic liver diseases, poses significant health challenges and carries a severe prognosis. This book provides a comprehensive review of the advancements in the diagnosis and management of liver cirrhosis and its complications. Spanning six chapters, this book delves into critical areas including diagnostic approaches and therapeutic strategies for cirrhosis, transarterial radioembolization (TARE) for hepatocellular carcinoma, the pathology of hepatic encephalopathy, and clinical applications of non-selective beta blockers (NSBBs) in cirrhosis management. Bringing together clinical and pathological perspectives, this book features contributions from esteemed authors worldwide. This multidisciplinary approach ensures a thorough understanding of the progress in diagnosing and managing cirrhosis and its complications. This book is designed to offer healthcare professionals, researchers, and students fresh insights and innovative approaches, aiming to enhance diagnostic and therapeutic practices for liver cirrhosis.
This book discusses the management of variceal bleeding in liver cirrhosis, covering a wide range of topics, including epidemiology, mechanism, diagnosis and monitoring, prophylaxis, treatment, and prognostic assessment. It also presents the latest research in the field, such as non-invasive approaches, self-expanding metal stents, hemostatic powder, and early TIPS. The book is a valuable resource for physicians wanting to establish standard treatment strategies, researchers launching innovative clinical and experimental studies, and also for patients and their relatives wishing to gain a better understanding of this disease.
Here's instant access to the symptoms, signs, differential diagnosis, and treatment for the full range of liver disorders. Written by an international 'who's who' of hepatology-and now in full color-this new 2nd Edition provides readers with top-notch, authoritative guidance they can count on! Discusses the hottest topics in the field, such as non-alcoholic steatohepatitis (NASH) and the latest information on liver transplantation. Includes expanded coverage of chronic hepatitis C, most notably the use of combination therapy with peginterferon and ribavirin and improvements in the management of the side effects of antiviral therapy. Offers the most recent therapeutic options for the management of chronic hepatitis B and advances in the understanding of the molecular biology of this virus. Updates the approach to the diagnosis of many liver diseases due to newer tests based on molecular techniques and advances in imaging. Features over 340 full-color illustrations. Uses a redesigned templated, outline format that makes reference a snap. Presents a concise, in-depth clinical summary-in an outline format-of the current practice of hepatology for each major disease entity. Provides a liberal use of tables, algorithms, and figures, rendering complex concepts understandable. Includes key point boxes at the beginning of each chapter, providing at-a-glance access to vital information. Includes alert symbols that highlight information that's critical to patient safety.
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
This book provides a unique up-to-date and comprehensive overview of the most important diagnostic methods available for assessing liver cirrhosis and portal hypertension. The book covers all the significant advances made in the last 10 years in HVPG and biopsy interpretation, imaging and elastography. This is a unique and well structured book authored by senior experts in the field aimed at providing updated knowledge to the hepatology specialist and to the physicians interested in chronic liver disease. The book starts by giving an overview of the disease, outlining the clinical needs in this field; this is followed by detailed information both on the invasive gold-standard methods (HVPG measurement, liver biopsy, endoscopy), and on the standard and emerging non-invasive methods, including serum markers of fibrosis, ultrasound-elastography, magnetic resonance elastography, ultrasound, contrast-enhanced ultrasound, CT, magnetic resonance and derived methods (dynamic flow assessment). The final part of the book is devoted to diagnostic tests in non-cirrhotic causes of portal hypertension (Budd-Chiari Syndrome, Portal vein thrombosis, idiopathic portal hypertension, etc), and in pediatric portal hypertension. Written by a team of worldwide opinion leaders this book pays special attention to the most promising novel non-invasive methods in the field.