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Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. - Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies - Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development - Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression - Provides information on new strategies and outstanding issues that should be addressed in future research
The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. 2018 BMA Medical Book Awards Highly Commended in Oncology - Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas - Edited by a prominent neurosurgeon with contributions by leading researchers in the field - Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors
Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. - Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development - New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies - Details IPR issues of translation, especially for public-private-partnerships - Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions
"This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fourth volume of Translational Immunology Series focuses on clinical and laboratory details of autoimmune diseases which are broadly categorized into two types of organ-specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Autoimmune rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis, autoimmune rheumatic diseases such as diabetes mellitus and thyroid diseases, autoimmune neurologic diseases such as multiple sclerosis, as well as autoimmune hepatobiliary diseases, autoimmune renal diseases and autoimmune cutaneous diseases as the subject of discussion in Translational Autoimmunity: Autoimmune Diseases in Different Organs. - Comprises major parts that cover basic immunology, clinical aspects of autoimmunity, and translational immunology studies in autoimmunity - Each and every key concept will be mentioned after an easy background is drawn and then, will be supported by a systematic appraisal of the most recent evidence - Can help students at all the academic levels while applicable to scientists who work with autoimmunity - Designed for learning, teaching, review and testing, practice, and research. Hence, it might be useful for students, teachers and instructors, physicians, and researchers
With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: Transplant-related complications Immune responses to transplants Emerging issues in transplantation Biomarkers of Allograft rejection and tolerance T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.
Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing. - Describes challenges in the diagnosis, management and treatment of autoimmune diseases - Highlights major difficulties in the diagnosis and management of autoimmune diseases - Reflects important remediable deficiencies in current management - Meets the needs of basic scientists, clinicians and translational scientists and industry partners