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Over the last 30 years, reactor safety technology has evolved not so much from a need to recover from accidents or incidents, but primarily from many groups in the nuclear community asking hypo thetical, searching (what if) ~uestions. This ~uestioning has indeed paid off in establishing preventive measures for many types of events and potential accidents. Conditions, such as reactivity excursions, large break, loss of coolant, core melt, and contain ment integrity loss, to name a few, were all at one time topics of protracted discussions on hypothesized events. Historically, many of these have become multiyear, large-scale research programs aimed at resolving the "what ifs. " For the topic of anticipated and abnormal plant transients, how ever, the searching ~uestions and the research were not so prolific until the mid-1970s. At that time, probabilistic risk methodolo gies began to tell us we should change our emphasis in reactor safety research and development and focus more on small pipe breaks and plant transients. Three Mile Island punctuated that message in 1979. The plant transient topic area is a multidisciplinary subject involving not only the nuclear, fluid flow, and heat transfer technologies, but also the synergistics of these with the reactor control systems, the safety s;,"stems, operator actions, maintenance and even management and the economic considerations of a given plant.
A clear, engaging writing style, hundreds of full-color images, and new information throughout make Volpe's Neurology of the Newborn, 6th Edition, an indispensable resource for those who provide care for neonates with neurological conditions. World authority Dr. Joseph Volpe, along with Dr. Terrie E. Inder and other distinguished editors, continue the unparalleled clarity and guidance you've come to expect from the leading reference in the field – keeping you up to date with today's latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology. - Provides comprehensive coverage of neonatal neurology, solely written by the field's founding expert, Dr. Joseph Volpe - for a masterful, cohesive source of answers to any question that arises in your practice. - Focuses on clinical evaluation and management, while also examining the many scientific and technological advances that are revolutionizing neonatal neurology. - Organizes disease-focused chapters by affected body region for ease of reference. - Features a brand new, full-color design with hundreds of new figures, tables, algorithms, and micrographs. - Includes two entirely new chapters: Neurodevelopmental Follow-Up and Stroke in the Newborn; a new section on Neonatal Seizures; and an extensively expanded section on Hypoxic-Ischemia and Other Disorders. - Showcases the experience and knowledge of a new editorial team, led by Dr. Joseph Volpe and Dr. Terrie E. Inder, Chair of the Department of Pediatric Newborn Medicine at Brigham and Women's Hospital, all of whom bring a wealth of insight to this classic text. - Offers comprehensive updates from cover to cover to reflect all of the latest information regarding the development of the neural tube; prosencephalic development; congenital hydrocephalus; cerebellar hemorrhage; neuromuscular disorders and genetic testing; and much more. - Uses an improved organization to enhance navigation. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
The 5th edition of this indispensable resource captures the latest insights in neonatal neurology in a totally engaging, readable manner. World authority Dr. Joseph Volpe has completely revised his masterwork from cover to cover, describing everything from the most up-to-the-minute discoveries in genetics through the latest advances in the diagnosis and management of neurologic disorders. He delivers all the clinical guidance you need to provide today's most effective care for neonates with neurological conditions. Provides comprehensive coverage of neonatal neurology, solely written by the field’s founding expert, Dr. Joseph Volpe - for a masterful, cohesive source of answers to any question that arises in your practice. Focuses on clinical evaluation and management, while also examining the many scientific and technological advances that are revolutionizing neonatal neurology. Organizes disease-focused chapters by affected body region for ease of reference. Offers comprehensive updates from cover to cover to reflect all of the latest scientific and clinical knowledge, from our most current understanding of the genetic underpinnings of neurologic disease, through the most recent neuroimaging advances . . . state-of-the-art guidelines for evaluation, diagnosis, and prognosis . . . and the newest management approaches for every type of neonatal neuropathology. Features a wealth of new, high-quality images that capture the many advances in neonatal neuroimaging, including numerous MR images.
This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
This book contains the most essential information needed for an epilepsy/ EEG rotation. Chapters are formatted with bullet points and feature clinical pearls. Concise and easy-to-read, this quick reference provides neurology residents, clinical neurophysiology and epilepsy fellows, and other clinicians with the most critical information in epilepsy and EEG in a simplified, yet comprehensive format. Divided into two sections, the book first covers the diagnosis, characteristics, and treatment of epilepsy. The second section focuses on EEG placement, procedures, and patterns in various neurological disorders.
Part of the highly regarded Biopsy Interpretation Series, this new volume by Drs. Laura M. Wake, Genevieve Crane, and Michael Borowitz presents a concise, pattern-based approach to bone marrow pathology. Biopsy Interpretation of the Bone Marrow provides superbly illustrated guidance from top experts in the field, covering all aspects of bone marrow aspirates and biopsies: procurement and processing, ancillary techniques, formulation of a final diagnosis, and reporting to the clinical team. Hundreds of full-color illustrations depict the full range of benign and neoplastic processes involving the bone marrow.
Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. Featuring a new structure and including new chapters, the third edition updates all content and presents considerable expansion on many topics, including: Metaphase cytogenetic and FISH Flow cytometry (overview and detailed analysis of specific tumors) Acute myeloid leukemia and new classification schemes MDS, AML, and B- and T-cell lymphoproliferations Abnormal patterns in the lymph node and bone marrow with detail differential diagnosis based on histologic features and cellular composition Detailed differential diagnosis based on the expression of broad list of antigenic markers (flow cytometry and immunohistochemistry) Extranodal lymphomas Diagnosis of MDS and myeloproliferative neoplasm and their differential diagnosis based on the morphologic, flow cytometric, and chromosomal features The book also provides expanded differential diagnosis of the most common as well as most difficult and rare entities, including morphologic, immunophenotypic, and karyotypic/molecular features. This edition includes updated algorithms for most common diagnoses as well as several new algorithms. The majority of figures have been revised and are in full color.
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis. This fourth edition: Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis Includes new diagnostic algorithms and summary boxes Contains 550 colour illustrations including high-quality digital photomicrographs Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.
This edition synthesizes state-of-the-art knowledge from a variety of disciplines, including clinical medicine, pathology, genetics, physiology, biochemistry and related fields. The primary focus is on clinical evaluation and management in the newborn; there is also coverage detailing the most sophisticated technology available for studying disturbances in the structure and function of the infantile nervous system.
The EEG is a simple and widely available neurophysiological test that, if interpreted correctly, can provide valuable insight into the functioning of the brain. However, despite its increasing usage in a range of settings, there is a common misconception that the EEG is inherently difficult to interpret. Compounding the problem is the lack of dedicated training and no standardized approach by encephalographers. This book provides a clear and concise guide to reading and interpreting EEGs in a systematic way. Presented in three sections, the first delivers foundational technical knowledge of how EEGs work, and the second concentrates on a comprehensive, stepwise approach to reading and interpreting an EEG. The third section contains examples of EEGs in common scenarios, such as seizures and post-cardiac arrest, enabling readers to correlate their findings to clinical indications. Heavily illustrated with over 200 example EEGs, this is an essential pocket guide to interpreting these tests.