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Rapid industrialization is a serious concern in the context of a healthy environment. With the growth in the number of industries, the waste generated is also growing exponentially. The various chemical processes operating in the manufacturing industry generate a large number of by-products, which are largely harmful and toxic pollutants and are generally discharged into the natural water bodies. Once the pollutants enter the environment, they are taken up by different life forms, and because of bio-magnification, they affect the entire food chain and have severe adverse effects on all life forms, including on human health. Although, various physico-chemical and biological approaches are available for the removal of toxic pollutants, unfortunately these are often ineffective and traditional clean up practices are inefficient. Biological approaches utilizing microorganisms (bacterial/fungi/algae), green plants or their enzymes to degrade or detoxify environmental pollutants such as endocrine disruptors, toxic metals, pesticides, dyes, petroleum hydrocarbons and phenolic compounds, offer eco- friendly approaches. Such eco-friendly approaches are often more effective than traditional practices, and are safe for both industry workers as well as environment. This book provides a comprehensive overview of various toxic environmental pollutants from a variety natural and anthropogenic sources, their toxicological effects on the environment, humans, animals and plants as well as their biodegradation and bioremediation using emerging and eco-friendly approaches (e.g. Anammox technology, advanced oxidation processes, membrane bioreactors, membrane processes, GMOs), microbial degradation (e.g. bacteria, fungi, algae), phytoremediation, biotechnology and nanobiotechnology. Offering fundamental and advanced information on environmental problems, challenges and bioremediation approaches used for the remediation of contaminated sites, it is a valuable resource for students, scientists and researchers engaged in microbiology, biotechnology and environmental sciences.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
This volume of the IARC Monographs provides evaluations of the carcinogenicity of pentachlorophenol, 2,4,6-trichlorophenol, 3,3',4,4'-tetrachloroazobenzene, aldrin, and dieldrin. Pentachlorophenol, aldrin, and dieldrin are classified as persistent organic pollutants under the Stockholm Convention. Pentachlorophenol has been widely used as a wood preservative and insecticide, but its production and use are now restricted. 2,4,6-Trichlorophenol has also been used as a wood preservative and insecticide, and in the synthesis of some fungicides. Aldrin and dieldrin are synthetic organochlorine pesticides used as broad-spectrum soil insecticides for the protection of various food crops, as seed dressings, and to control infestations of pests such as ants and termites. In several countries their use has been banned or severely restricted since the early 1970s. 3,3',4,4'-Tetrachloroazobenzene is not manufactured commercially but is formed during the production and degradation of chloroanilide herbicides such as propanil, linuron, and diuron. Exposure to all five agents considered may occur in the general population as well as in various occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure of these agents.