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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Covers the design or redesign of chemicals with the specific intent of making them safe for people and the environment. Explains how commercially useful substances of low toxicity can be designed and developed through careful forethought and strategic molecular modification. Describes how existing industrial chemicals that are toxic can be redesigned to be less toxic but retain their usefulness. Discusses how to merge the disciplines of toxicology and chemistry to design new, less toxic commercial chemicals or redesign existing toxic commercial chemicals to result in less toxic substitutes. Provides researchers, developers, and manufacturers of industrial chemicals with a reference source for designing safer chemicals.