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The Clinical Guide serves as a reference tool for clinicians in the administration of transcranial magnetic stimulation (TMS) for neuropsychiatric disorders. The primary intent of this Guide is to focus on the clinical applications of TMS and to offer detailed information on the safe and effective administration of TMS with consideration of the neurophysiological effects particularly in relation to safety, targeting specific cortical areas and practical issues such as the length of treatment sessions and the durability of the TMS response. The Guide focuses on the evidenced based literature and utilizes this literature to inform specific recommendations on the use of rTMS in a clinical setting. The efficacy and safety of TMS for neuropsychiatric disorders, including its use in special populations, such as the elderly, will be reviewed to facilitate clinical decision-making. The Guide will also outline setting up a TMS service including practical issues such as considerations for the qualifications of the person administering the treatment, the use of concomitant medications, what equipment is necessary to have in the treatment room and monitoring the outcomes to treatment. The Guide is intended to be a practical reference for the practicing clinician in the safe and effective administration of TMS.
Business Ethics provides a thorough review and analysis of business ethics issues using several learning tools: Strategic Stakeholder Management as the Theme: All chapters use a strategic stakeholder approach as a unifying theme. The text is thus the first text that adopts this approach. Most business ethics scholars and practitioners agree that successful ethical companies are the ones that can strategically balance the needs of their various stakeholders. By adopting this approach, students will be able to see how the various aspects of business ethics are connected. Theory-based and Application-based: All chapters have important applicable theories integrated with discussion of how such theories apply in practice. Unlike other texts that are either too theoretical or too practical, this text provides the appropriate blend of theory and practice to provide deeper insights into the concepts covered in the chapter. Global Perspective: Unless most other texts, this text provides a global perspective on business ethics. Most chapters include material pertaining to ethics in global contexts. Included are cases about companies in a wide range of countries including Japan, U.K., China and India among many others. Cases: The text contains over 30 real world global cases. Each chapter ends with a short two page case as well as a longer case that varies in length. Each has discussions questions at the end. Finally each of the four parts ends with a Comprehensive Case; proven teaching cases from The Ivey School and other sources.
This collection explores all aspects of metallurgical processing, materials behavior, and microstructural performance for the distinct class of 718-type superalloys and derivatives. Technical topics focus on alloy and process development, production, product applications, trends, and the development of advanced modeling tools. New developments in R&D, new processing methods, 3D printing, and other nontraditional applications also are covered.
Robotized Transcranial Magnetic Stimulation describes the methods needed to develop a robotic system that is clinically applicable for the application of transcranial magnetic stimulation (TMS). Chapter 1 introduces the basic principles of TMS and discusses current developments towards robotized TMS. Part I (Chapters 2 and 3) systematically analyzes and clinically evaluates robotized TMS. More specifically, it presents the impact of head motion on the induced electric field. In Part II (Chapters 3 to 8), a new method for a robust robot/camera calibration, a sophisticated force-torque control with hand-assisted positioning, a novel FTA-sensor for system safety, and techniques for direct head tracking, are described and evaluated. Part III discusses these developments in the context of safety and clinical applicability of robotized TMS and presents future prospects of robotized TMS. Robotized Transcranial Magnetic Stimulation is intended for researchers as a guide for developing effective robotized TMS solutions. Professionals and practitioners may also find the book valuable.
These papers present advancements in all aspects of high temperature electrochemistry, from the fundamental to the empirical and from the theoretical to the applied. Topics involving the application of electrochemistry to the nuclear fuel cycle, chemical sensors, energy storage, materials synthesis, refractory metals and their alloys, and alkali and alkaline earth metals are included. Also included are papers that discuss various technical, economic, and environmental issues associated with plant operations and industrial practices.
This book describes the past, present and future of dialysis and dialysis-related renal replacement therapies so that the reader can acquire a firm grasp of the medical management of acute and chronic renal failure. By becoming thoroughly conversant with the past and present of dialysis, a health care professional will be in a much better position to provide the best standard of care to patients suffering from renal failure. As the book highlights the unsolved operational obstacles in the field of renal replacement therapies, future innovators may be inspired to develop novel solutions to tackle these problems. This remarkable work is a must-read not just for health care providers in the dialysis industry, but for patients, dialysis equipment manufacturers as well as pharmaceutical companies.
Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select. Each chapter in Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is dedicated to one drug, with each containing information on: worldwide sales and patent status of the Active Pharmaceutical Ingredient (API); structure analysis and general retrosynthetic strategy of the API; first reported synthesis; critical analysis of the processes which have been developed and comparison of the synthetic routes; lessons learned; reaction conditions for Schemes A to X; chemical "highlights" on key reactions used during the synthesis; and references. Drugs covered include: Gabapentin, Clopidogrel, Citalopram and Escitalopram, Sitagliptin, Ezetimibe, Montelukast, and Oseltamivir. Show how the retrosynthetic tool is used by the Pharmaceutical Industry Fills a gap for a book where retrosynthetic analysis is systematically applied to active pharmaceutical ingredients (APIs) Features analyses and methodologies that aid readers in uncovering practical synthetic routes to other drug substances, whether they be NCEs (New Chemical Entities) or generic APIs (Active Pharmaceutical Ingredients) Presents information from both the patent and academic literature for those who wish to use as a basis for further study and thought Features the use of "reaction maps" which display several synthetic processes in the same scheme, and which allow easy comparisons of different routes that give the same molecule or intermediate. A selection of these maps are available to download from: https://www.wiley.com/go/santos/retrosynthesis Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is an ideal book for researchers and advanced students in organic synthetic chemistry and process chemistry. It will also be of great benefit to practitioners in the pharmaceutical industry, particularly new starters, and those new to process chemistry.
This collection offers new research findings, innovations, and industrial technological developments in extractive metallurgy, energy and environment, and materials processing. Technical topics included in the book are thermodynamics and kinetics of metallurgical reactions, electrochemical processing of materials, plasma processing of materials, composite materials, ionic liquids, thermal energy storage, energy efficient and environmental cleaner technologies and process modeling. These topics are of interest not only to traditional base ferrous and non-ferrous metal industrial processes but also to new and upcoming technologies, and they play important roles in industrial growth and economy worldwide.
A superalloy, or high-performance alloy, is an alloy that exhibits excellent mechanical strength at high temperatures. Superalloy development has been driven primarily by the aerospace and power industries. This compilation of papers from the Twelfth International Symposium on Superalloys, held from September 9-13, 2012, offers the most recent technical information on this class of materials.
The Light Metals symposia are a key part of the TMS Annual Meeting & Exhibition, presenting the most recent developments, discoveries, and practices in primary aluminum science and technology. Publishing the proceedings from these important symposia, the Light Metals volume has become the definitive reference in the field of aluminum production and related light metal technologies. The 2014 collection includes papers from the following symposia: •Alumina and Bauxite •Aluminum Alloys: Fabrication, Characterization and Applications •Aluminum Processing •Aluminum Reduction Technology •Cast Shop for Aluminum Production •Electrode Technology for Aluminum Production •Light-metal Matrix (Nano)-composites