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Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.
Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.
This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
SECTION 1: CLINICAL SECTION 2: DIAGNOSIS SECTION 3: TENECTEPLASE (TNK) AND CLOT TREATMENT SECTION 4: NOACs IN CLOT TREATMENT SECTION 5: THROMBOSIS AND CORONARY ARTERY DISEASE SECTION 6: THROMBOSIS AND HYPERTENSION SECTION 7: THROMBOSIS AND HEART FAILURE SECTION 8: THROMBOSIS AND DYSLIPIDEMIA SECTON 9: THROMBOSIS AND DIABETES MELLITUS SECTION 10: THROMBOSIS AND ARRHYTHMIA SECTION 11: THROMBOSIS AND CARDIOMYOPATHY SECTION 12: THROMBOSIS AND RHD SECTION 13: DVT SECTION 14: THROMBOSIS AND PAD SECTION 15: THROMBOSIS AND CAROTID ARTERY DISEASE SECTION 16: THROMBOSIS AND VERTEBRAL ARTERY DISEASE SECTION 17: THROMBOSIS AND STROKE INTRACEREBRAL ARTERIAL DISEASE SECTION 18: THROMBOSIS AND KIDNEY SECTION 19: THROMBOSIS AND CARDIAC SURGERY SECTION 20: THROMBOSIS AND CRITICAL CARE SECTION 21: THROMBOSIS IN EMERGENCY AND URGENT CARE SECTION 22: THROMBOSIS AND SEPSIS SECTION 23: THROMBOSIS AND WOMEN SECTION 24: THROMBOSIS AND EYE SECTION 25: THROMBOSIS AND LUNG SECTION 26: NOAC AND DRUGS INTERACTION SECTION 27: COVID-INFLICTED COAGULOPATHY SECTION 28: CLOT IN ECMO SECTION 29: THROMBOSIS AND COVID VACCINATION SECTION 30: THROMBOSIS AND NUTRITION SECTION 31: CARDIO-ONCOLOGY AND THROMBOSIS SECTION 32: POSTMITRAL CLIP THROMBOSIS SECTION 33: PEDIATRICS AND THROMBOSIS SECTION 34: SKIN AND THROMBOSIS SECTION 35: THROMBOSIS AND AVN SECTION 36: FUTURE DIRECTIONS IN THROMBOSIS CARE
Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.