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This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.
Neuronal Noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations. The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise. It provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area. It also provides the specialist with a summary of the large body of sometimes contrasting experimental data, and different theories proposed to explore the computational power that various forms of "noise" can confer to neurons.
Following the successful format of the first volume on long-term potentiation--a leading candidate for the neuronal basis of learning and memory--Volume 2 brings together the most recent data and hypotheses by top neuroscientists regarding the mechanisms of this phenomenon and of long-term depression (LTD).Following the successful format of the first volume on long- term potentiation--a leading candidate for the neuronal basis of learning and memory--Volume 2 brings together the most recent data and hypotheses by top neuroscientists regarding the mechanisms of this phenomenon and of long-term depression (LTD). The book is divided into several sections covering different aspects of the field ranging from molecular mechanisms of plasticity to computational neurobiology. It revisits some of the major points covered in Volume 1, updating them in this fast-moving field. It also introduces several new issues that have arisen since then. Of the many possible new topics that could have been added, the editors have focused on retrograde messengers and the mechanisms and functions of LTP and LTD because they are the subject of much interest, research, and controversy. The section on retrograde messengers deals primarily with nitric oxide.
The authoritative reference on NEURON, the simulation environment for modeling biological neurons and neural networks that enjoys wide use in the experimental and computational neuroscience communities. This book shows how to use NEURON to construct and apply empirically based models. Written primarily for neuroscience investigators, teachers, and students, it assumes no previous knowledge of computer programming or numerical methods. Readers with a background in the physical sciences or mathematics, who have some knowledge about brain cells and circuits and are interested in computational modeling, will also find it helpful. The NEURON Book covers material that ranges from the inner workings of this program, to practical considerations involved in specifying the anatomical and biophysical properties that are to be represented in models. It uses a problem-solving approach, with many working examples that readers can try for themselves.
This volume includes papers presented at the Fifth Annual Computational Neurosci ence meeting (CNS*96) held in Boston, Massachusetts, July 14 - 17, 1996. This collection includes 148 of the 234 papers presented at the meeting. Acceptance for mceting presenta tion was based on the peer review of preliminary papers originally submitted in May of 1996. The papers in this volume represent final versions of this work submitted in January of 1997. As represented by this volume, computational neuroscience continues to expand in quality, size and breadth of focus as increasing numbers of neuroscientists are taking a computational approach to understanding nervous system function. Defining computa tional neuroscience as the exploration of how brains compute, it is clear that there is al most no subject or area of modern neuroscience research that is not appropriate for computational studies. The CNS meetings as well as this volume reflect this scope and di versity.
This book reviews the molecular components and ionic mechanisms underlying sleep oscillations, including the properties of ion channels, synaptic receptors and the patterns of interconnectivity among thalamic and cortical neurons. These properties have been used to build detailed computational models of thalamocortical assemblies and their collective behavior.
Brain Inspired Cognitive Systems - BICS 2010 aims to bring together leading scientists and engineers who use analytic and synthetic methods both to understand the astonishing processing properties of biological systems and specifically of the brain, and to exploit such knowledge to advance engineering methods to build artificial systems with higher levels of cognitive competence. BICS is a meeting point of brain scientists and cognitive systems engineers where cross-domain ideas are fostered in the hope of getting emerging insights on the nature, operation and extractable capabilities of brains. This multiple approach is necessary because the progressively more accurate data about the brain is producing a growing need of a quantitative understanding and an associated capacity to manipulate this data and translate it into engineering applications rooted in sound theories. BICS 2010 is intended for both researchers that aim to build brain inspired systems with higher cognitive competences, and for life scientists who use and develop mathematical and engineering approaches for a better understanding of complex biological systems like the brain. Four major interlaced focal symposia are planned for this conference and these are organized into patterns that encourage cross-fertilization across the symposia topics. This emphasizes the role of BICS as a major meeting point for researchers and practitioners in the areas of biological and artificial cognitive systems. Debates across disciplines will enrich researchers with complementary perspectives from diverse scientific fields. BICS 2010 will take place July 14-16, 2010, in Madrid, Spain.
This volume presents the proceedings of the joint conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC), held in Tampere, Finland, in June 2017. The proceedings present all traditional biomedical engineering areas, but also highlight new emerging fields, such as tissue engineering, bioinformatics, biosensing, neurotechnology, additive manufacturing technologies for medicine and biology, and bioimaging, to name a few. Moreover, it emphasizes the role of education, translational research, and commercialization.
High quality papers are requested containing original contributions to engineering, physics, mathematical, algorithmic, clinical and translational aspects of systems in medicine and biology