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This book provides a comprehensive overview of the multitude of different forms of thermotherapy in connection with aspects of thermal physiology and cell biology. The aim is to elucidate the scientific background of therapeutic actions and to promote effective new applications at the beginning of the 21st century. Significant to these purposes is cooperation between experts in the fields of thermal biology, hyper thermic oncology, rheumatology, and balneology, as represented by the editors. Emphasis has been placed on a balanced choice of contributions, in the hope that this will enable the reader to draw helpful connections between the principles and prac tice of thermotherapy. It is apparent that a wealth of published data exists concerning thermotherapy on the one hand and thermal physiology on the other. However, in the former field empirical aspects of therapeutic usefulness prevail, while in the latter, aspects of basic science are in the foreground. Accordingly, the sources where published data may be found are quite different and as a consequence many findings of potential mutual interest published in medical journals have gone unnoticed by readers of physio logical journals, and vice versa. It is hoped that this book will bridge the gap and encourage researchers' efforts to integrate the available knowledge to attain optimal coordination of clinical and theoretical aspects.
This edited volume records the critical historical developments in thermal physiology and makes them accessible to new and senior thermal biologists and scientists in related fields. Readers will discover how the discipline developed all over the world. Contributions from 14 different countries recollect all prominent discoveries, starting in the 18th century. Like other volumes of the Perspectives in Physiology series, this book reveals the people behind these discoveries. The authors also set the scenes in which the research was conducted in their countries. From geopolitical frameworks to new technologies and extraordinary personalities - this volume shows that scientific progress is influenced by many, often unforeseeable, factors. The history of thermal physiology not only is a story about individual outstanding scientists, but a testament for open collaboration and international comradery.
The next generation of oncological hyperthermia involves the medical innovation of selectively heating up the malignant cells of the body in a controlled way. The easily-distinguishable biophysical and physiological characteristics of cancer cells and their immediate environment are the focus of the targeted energy delivery of this treatment. This heterogenic heating concept breaks with the homogeneous nature of conventional hyperthermia, where an isothermally equal temperature is applied to the large surface area of a solid tumor. Due to its selectivity, the new concept enables the usage of a significantly lower energy, making it safer, less toxic, and easier to use. This book shows the challenges facing oncological hyperthermia, and highlights clinical results obtained in various countries. It also presents discussions about the theoretical basis of the method, adding some technical discussions and clarifying the most difficult points of its design. The contributions dealing with clinical results use state-of-art conventional therapies with complementary hyperthermia and show the advantages of such a combination.
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.
This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer. In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer. This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.
Availability of and adequate accessibility to freshwater and energy are two key technological and scientific problems of global significance. At the end of the 20th century, the deficit of water for human consumption and economic application forced us to focus on rational use of resources. Increasing the use of renewable energy sources and improving energy efficiency is a challenge for the 21st century. Geothermal energy is heat energy generated and stored in the Earth, accumulated in hydrothermal systems or in dry rocks within the Earth’s crust, in amounts which constitute the energy resources. The sustainable management of geothermal energy resources should be geared towards optimization of energy recovery, but also towards rational management of water resources since geothermal water serves both as energy carrier and also as valuable raw material. Geothermal waters, depending on their hydrogeothermal characteristics, the lithology of the rocks involved, the depth at which the resources occur and the sources of water supply, may be characterized by very diverse physicochemical parameters. This factor largely determines the technology to be used in their exploitation and the way the geothermal water can be used. This book is focused on the effective use of geothermal water and renewable energy for future needs in order to promote modern, sustainable and effective management of water resources. The research field includes crucial new areas of study: • an improvement in the management of freshwater resources through the use of residual geothermal water; • a review of the technologies available in the field of geothermal water treatment for its (re)use for energetic purposes and freshwater production, and • the development of balneotherapy. The book is aimed at professionals, academics and decision makers worldwide, water sector representatives and administrators, business enterprises specializing in renewable energy management and water treatment, working in the areas of geothermal energy usage, water resources, water supply and energy planning. This book has the potential to become a standard text used by educational institutions and research & development establishments involved in the geothermal water management.
The book is designed to provide a flowing description of the physiology of heat stress, the illnesses associated with heat exposure, recommendations on optimising health and performance, and an examination of Olympic sports played in potentially hot environmental conditions. In the first section the book examines how heat stress effects performance by outlining the basics of thermoregulation and how these responses impact on cardiovascular, central nervous system, and skeletal muscle function. It also outlines the pathophysiology and treatment of exertional heat illness, as well as the role of hydration status during exercise in the heat. Thereafter, countermeasures (e.g. cooling and heat acclimation) are covered and an explanation as to how they may aid in decreasing the incidence of heat illness and minimise the impairment in performance is provided. A novel and particular feature of the book is its inclusion of sport-specific chapters in which the influence of heat stress on performance and health is described, as well as strategies and policies adopted by the governing bodies in trying to offset the deleterious role of thermal strain. Given the breadth and scope of the sections, the book will be a reference guide for clinicians, practitioners, coaches, athletes, researchers, and students.
The book "Hyperthermia", published by InTech, and edited by Dr. Nagraj Huilgol, of the Department of Radiation Oncology, Dr. Balabhai Nanavati Hospital, India, is comprised of 8 Open Access chapters, covering a wide range of Hyperthermia-related scientific research.
Fighting Cancer describes the Gorter Model, an integrative, nontoxic approach to cancer treatment that mobilizes the immune system. It was developed by Robert Gorter, MD, PhD, who in 1976 recovered from Stage IV testicular cancer by using nontoxic treatment and no chemotherapy or radiation. Based on self-experience, extensive research, and decades of clinical practice, the treatment consists of supporting the immune system using fever therapy (hyperthermia), inoculation with immune cells, the use of the botanical mistletoe (Viscum album)—the single most commonly prescribed anti-cancer medication in much of Europe—supportive nutrients, and diet and lifestyle changes. Organized into three parts, Fighting Cancer presents a clear overview of the model, the research behind it, and strategies for strengthening natural immunity. Emphasizing stress reduction and minimizing toxic exposure, the authors provide practical guidance for patients: questions to ask doctors after diagnosis and advice for evaluating options, gathering information, and getting second opinions. Included are powerful testimonials from patients—most of whom have outlived their prognosis and, in some cases, achieved complete and sustained remission.