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This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
New COVID-19 Variants - Diagnosis and Management in the Post-Pandemic Era provides a comprehensive overview of COVID-19, focusing on new variants and their diagnosis, treatment, and prevention. Due to the emergence of new viral variants, cases of COVID-19 are expected to increase. Thus, it is vital to take the necessary precautions to protect society and its most vulnerable members like the elderly and immunocompromised. This book discusses protective measures such as social distancing, mask mandates, vaccinations, and more.
Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how ever, known about the factors influencing and responsible for the dramatically diverse patterns of virus variability. II. MUTATION RATE AND VARIABILITY OF HUMAN AND ANIMAL VIRUSES Mutation is undoubtedly the primary source of variation, and several reports in the literature suggest that extreme variability of some viruses may be a consequence of an unusually high mutation rate (Holland et al., 1982; Domingo et al., 1985; Smith and Inglis, 1987). The mutation rate of a virus is defined as the probability that during a single replication of the virus genome a particular nucleotide position is altered through substitution, deletion, insertion. or recombination. Different techniques have been utilized to measure virus mutation rates, and these have been noted in the extent of application to different viruses.
This open access book provides a comprehensive analysis of the socioeconomic determinants of Covid-19. From the end of 2019 until presently, the world has been ravaged by the Covid-19 pandemic. Although the cause of this is (obviously) a virus, the extent to which this virus spread, and therefore the number of infections and deaths, was largely determined by socio-economic factors. From this, it follows that the course of the pandemic varies greatly from one country to another. This observation applies both to countries’ resilience to such a pandemic (which is mainly rooted in the period preceding the outbreak of the virus) and to the way in which countries have reacted to the virus (including the political choices on how to respond). Meanwhile, research has made it clear that the nature of this response (e.g., elimination policy, mitigation policy, and proceeding herd immunity) was, on the one hand, strongly determined by political and ideological factors and, on the other hand, was highly influential in the factors of success or failure in combating the pandemic. The book focuses on the situation in a number of Western regions (notably the USA, the UK, and the EU and its Member States). The author addresses the reasons why in many Western countries both pandemic prevention and response policies to Covid-19 have failed. The book concludes with recommendations concerning the rearrangement of the socio-economic order that could increase the resilience of (Western) societies against such pandemics.
This textbook provides the basic concepts of epidemiology while preparing readers with the skills of applying statistical tools in real-life situations. Students, in general, struggle with statistical theories and their practical applications. This book makes statistical concepts easy to understand by focusing on real-life examples, case studies, and exercises. It also provides step-by-step guides for data analysis and interpretation using standard statistical software such as SPSS, SAS, R, Python, and GIS as appropriate, illustrating the concepts. Through the book's 23 chapters, readers primarily learn how to apply statistical methods in epidemiological studies and problem-solving. Among the topics covered: Clinical Trials Epidemic Investigation and Control Geospatial Applications in Epidemiology Survival Analysis and Applications Using SAS and SPSS Systematic Review and Meta-Analysis: Evidence-based Decision-Making in Public Health Missing Data Imputation: A Practical Guide Artificial Intelligence and Machine Learning Multivariate Linear Regression and Logistics Regression Analysis Using SAS Each chapter is written by eminent scientists and experts worldwide, including contributors from institutions in the United States, Canada, Bangladesh, India, Hong Kong, Malaysia, and the Middle East. Statistical Approaches for Epidemiology: From Concept to Application is an all-in-one book that serves as an essential text for graduate students, faculty, instructors, and researchers in public health and other branches of health sciences, as well as a useful resource for health researchers in industry, public health and health department professionals, health practitioners, and health research organizations and non-governmental organizations. The book also will be helpful for graduate students and faculty in related disciplines such as data science, nursing, social work, environmental health, occupational health, computer science, statistics, and biology.
The most complete and definitive reference to all aspects of poultry diseases, Diseases of Poultry, Fourteenth Edition has been fully revised and updated to offer a comprehensive survey of current knowledge. Updates the definitive reference of poultry health and disease Provides more clinically relevant information on management of specific diseases, contributed by clinical poultry veterinarians Offers information on disease control in organic and antibiotic-free production Presents more concise, streamlined chapters for ease of use Incorporates advances in the field, from new diagnostic tools and information to changes brought about by the increasing globalization and the re-emergence of zoonotic pathogens