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WHEN VARIANT SQUAD Captain Joe Borland works up the nerve to take care of some long-overdue business, he stumbles upon the terrifying shape of things to come. Dreams and reality collide in the shadow of the Variant Effect. Joe Borland returns in PAINKILLER, a gut-wrenching novella of grisly horror that takes place between the events in The Variant Effect books: SKIN EATERS and GREENMOURNING. It's been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now both of them are being ordered back into action to meet the new threat.
THE VARIANT SQUAD barely had time to get back on its feet before the screaming started. Someone was getting skinned alive, and they knew it. But many of their comrades have just fallen to their deaths, and others are still missing, so Captain Beachboy knows that answering the cry for help would be suicide. Skin Eater packs are still hunting on the levels above and below them, and it’s only a matter of time before their ugly craving returns and they attack again. And that’s not the end of it. A murderous Kill Squad sent by an unknown enemy must have followed them underground. It has the Lazarus team’s innocent blood on its hands, and Beachboy suspects the unknown assassins are committed to spilling 9-Squad’s too. And the old myths about the basement are proving true. Something with an appetite for pain is haunting the bunker complex and feeds its hunger through the Biter packs. It has also poisoned the place with the Varion molecule that causes the lethal new form of the Variant Effect, forcing the squad to remain sealed in their bag-suits. And they’re running out of air. Variant Squad veteran Joe Borland knows that there are forces within the squad that might not want to win the battle underground, and would prefer leaving his bagged-comrades buried with the incriminating evidence they have found. So he’ll have to pick a side when his life’s on the line. In the meantime he and Beachboy take the squad survivors on a desperate search for a rumored escape tunnel while dark forces gather on all sides, and a secret clock winds down to doomsday and the final Variant Squad protocol of Ziploc, Gas and BURN! Explore the MADHOUSE to the END with BURN, third stage in the final chapters of The Variant Effect Series.
JOE BORLAND and Captain Beachboy deliver Lazarus team scientists to Bezo Metro Headquarters and find things in upheaval, so the rest of 9-Squad is ordered in to provide security. The Variant Squad has been shaken and bloodied over the last twenty-four hours with a rising body count, and there hasn’t been time for wounds to heal or for the dead recruits to be replaced. But the Bezo Board of Directors has put Lazarus specialists in charge of efforts to halt the Variant Effect outbreak in Metro, and end the Ziploc that holds the city in quarantine. The veterans Borland and Hyde are suspicious of the change in command but cannot override their questionable orders or abandon their squad to a dubious mission. As they prepare to join the scientists underground and open research labs that have been sealed for decades, 9-Squad finds the enigmatic company man, Brass, is working the graveyard shift and overseeing a top secret project of his own. Brass is in survival mode and his “Plan B” has hit a few bumps, but that’s not the worst of it. There have been reports of unusual sounds and sightings that lend some truth to the old rumors that the HQ basement levels are haunted. The squad must investigate the eerie phenomena, but all the signs point to something far more tangible and terrifying than the dead. Borland, Hyde and the frazzled 9-Squad must decide who they can trust as lethal forces gather, and avenues of escape begin to close. The only way to save their skins and protect the public from annihilation may involve a terrifying descent into darkness. Explore the MADHOUSE with Gas Light, second stage in the final chapters of The Variant Effect Series.
Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.
M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.
WHILE HYDE hunts for a Variant-enhanced serial killer, a fight with a skin-eating granny almost sends Borland back into retirement. Skin eaters, secrets, and murder close in as the squad scrambles to contain the Variant Effect. VARION was a popular medication that could cure anything from Anxiety and Depression to Schizophrenia and Zoophagia. Everybody took it back in the day, because there were no side effects ... AT FIRST. By the time they learned about the Variant Effect it was too late. It’s been twenty years since Borland battled the Variant Effect, and twenty since he let his partner get skinned alive. Now they have been ordered back into action to meet a terrifying new threat.
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
This study examines the condition known as parkinsonism of early onset with diurnal fluctuation (PEDF). It aims to clarify the differences between PEDF and early-onset Parkinson disease, then to compare PEDF with HPD (hereditary progressive dystonia with marked diurnal fluctuation).