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For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
The essential, cornerstone book of modern environmentalism is now offered in a handsome 40th anniversary edition which features a new Introduction by activist Terry Tempest Williams and a new Afterword by Carson biographer Linda Lear.
Praised for its ability to kill insects effectively and cheaply and reviled as an ecological hazard, DDT continues to engender passion across the political spectrum as one of the world's most controversial chemical pesticides. In DDT and the American Century, David Kinkela chronicles the use of DDT around the world from 1941 to the present with a particular focus on the United States, which has played a critical role in encouraging the global use of the pesticide. Kinkela's study offers a unique approach to understanding both this contentious chemical and modern environmentalism in an international context.
Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.
"The Mosquito Wars is a fascinating chronicle of the history of mosquito control in Florida over the past century. It details the positive contributions made by the profession's many managers and scientists. This work thoroughly describes how this profession has helped make Florida habitable and also puts the environmental controversies of mosquito control in the proper perspective."--Douglas Carlson, Indian River Mosquito Control District "The Mosquito Wars is an entertaining, accurate description of how mosquito control has developed in Florida to its current state."--Dennis Moore, editor-in-chief, Wing Beats The Mosquito Wars presents a comprehensive and insightful analysis of the development of human efforts to wage war on mosquitoes in 20th-century Florida. Drawing on archival records, interviews, and published records, Gordon Patterson provides readers with a context for understanding how mosquito control has shaped the environment of contemporary Florida. Patterson reveals how the discovery that yellow fever, malaria, and dengue fever were mosquito-borne diseases had a profound impact on Florida's development in the first half of the 20th century. State agencies organized campaigns from Pensacola to Key West against the disease-bearing insects. World War II opened a new era in mosquito control; the United States Department of Agriculture pioneered the use of DDT as an insecticide, and by 1944 army and navy pilots were regularly flying anti-mosquito missions. The 1950s ushered in a new objective--to reduce not only disease-bearing mosquitoes but also pest and nuisance mosquitoes. The growing problem of chemical resistance, however, led to the use of new and more powerful pesticides, raising concerns about the environmental impact of these chemicals on biologically sensitive wetlands. The ensuing controversy resulted in the rewriting of mosquito control laws in 1986. The continuing occurrences of encephalitis and the recent arrival of the West Nile virus, both transmitted by mosquitoes, dictate that mosquito control will continue to play a vital role in protecting the public's health and welfare. The Mosquito Wars presents a balanced, entertaining, and informative examination of this often heroic and sometimes tragic history of the battle to control mosquitoes in Florida. Gordon Patterson is professor of history at the Florida Institute of Technology, Melbourne.
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
**The instant New York Times bestseller.** *An international bestseller.* Finalist for the Lane Anderson Award Finalist for the RBC Taylor Award “Hugely impressive, a major work.”—NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity’s fate Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power. The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village. Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history and her indelible impact on our modern world order.
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.