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From the world of Sir Arthur Conan Doyle's Sherlock Holmes comes The Time Between Heartbeats ~ a novel featuring time travel and an unexpected romance. While on holiday, Detective Inspector Geoff Lestrade is hurtled through time to 1513 Scotland and finds himself the guest of Laird Mycroft Holmes. Geoff thinks it all an elaborate ruse by the "British Government," aka 21st Century Mycroft Holmes, to kidnap him. Putting his detective skills to work, he does his best to find evidence that would support his presumption, but as the days pass, he can only come to one conclusion. Time travel doesn't require advanced computer programming and elaborate machinery. All it takes is a divine cupid and a time portal. The arrival of a man from the future isn't something Laird Mycroft Holmes would have ever expected, since past time travelers have always been women. Why is the latest arrival a man from the 21st century? While Geoff bides his time before he can attempt a return home through the time portal, friendship between them flourishes, but each resists the attraction blossoming between them. Geoff's decision to go back to the 21st century becomes harder and harder. Return to the conveniences of the modern era or remain with the love of his life? A love that could endanger not only Geoff and Mycroft, but Mycroft's family as well. Join Geoff and Mycroft on the adventure of a lifetime.
New edition of the classic complete reference book for cardiologists and trainee cardiologists on the theory and practice of electrocardiography, one of the key modalities used for evaluating cardiology patients and deciding on appropriate management strategies.
"Body Physics was designed to meet the objectives of a one-term high school or freshman level course in physical science, typically designed to provide non-science majors and undeclared students with exposure to the most basic principles in physics while fulfilling a science-with-lab core requirement. The content level is aimed at students taking their first college science course, whether or not they are planning to major in science. However, with minor supplementation by other resources, such as OpenStax College Physics, this textbook could easily be used as the primary resource in 200-level introductory courses. Chapters that may be more appropriate for physics courses than for general science courses are noted with an asterisk symbol (*). Of course this textbook could be used to supplement other primary resources in any physics course covering mechanics and thermodynamics"--Textbook Web page.
This volume aims to introduce organizational researchers and practitioners to the role of neuroscience in building theory, research methodologies and practical applications. The volume introduces the field of organizational neuroscience and explores its influence on topics such as leadership, ethics and moral reasoning.
One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
Nerve endings in the walls of the carotid sinuses and the aortic arch transduce arterial pressure changes and provide the central nervous system with a steady stream of encoded information. On the basis of this information, efferent autonomic neural activity is modulated finely, and the neurohumoral milieu of the heart and the blood vessels is adjusted on a second-to-second basis. The arterial baroreflex may be the most important of the cardiovascular control mechanisms, because the baroreflex, above all other reflex mechanisms, is the one whose speed is most adequate to respond rapidly to the abrupt transients of arterial pressure that occur in daily life. This volume presents the many experimental methods available for use in humans that have been recently developed. Some are ingenious and yield results that earlier might have been thought impossible to obtain from human volunteers. Development of these new methods has increased the scientific credibility of human baroreflex research, and this work discusses the advances made in these studies. It clearly describes the existing deficiencies in the understanding of baroreflex mechanisms, and suggests methods for future research in this developing field.
Over the last decades, assessment of heart rate variability (HRV) has increased in various fields of research. HRV describes changes in heartbeat intervals, which are caused by autonomic neural regulation, i.e. by the interplay of the sympathetic and the parasympathetic nervous systems. The most frequent application of HRV is connected to cardiological issues, most importantly to the monitoring of post-myocardial infarction patients and the prediction of sudden cardiac death. Analysis of HRV is also frequently applied in relation to diabetes, renal failure, neurological and psychiatric conditions, sleep disorders, psychological phenomena such as stress, as well as drug and addiction research including alcohol and smoking. The widespread application of HRV measurements is based on the fact that they are noninvasive, easy to perform, and in general reproducible – if carried out under standardized conditions. However, the amount of parameters to be analysed is still rising. Well-established time domain and frequency domain parameters are discussed controversially when it comes to their physiological interpretation and their psychometric properties like reliability and validity, and the sensitivity to cardiovascular properties of the variety of parameters seems to be a topic for further research. Recently introduced parameters like pNNxx and new dynamic methods such as approximate entropy and detrended fluctuation analysis offer new potentials and warrant standardization. However, HRV is significantly associated with average heart rate (HR) and one can conclude that HRV actually provides information on two quantities, i.e. on HR and its variability. It is hard to determine which of these two plays a principal role in the clinical value of HRV. The association between HRV and HR is not only a physiological phenomenon but also a mathematical one which is due to non-linear (mathematical) relationship between RR interval and HR. If one normalizes HRV to its average RR interval, one may get ‘pure’ variability free from the mathematical bias. Recently, a new modification method of the association between HRV and HR has been developed which enables us to completely remove the HRV dependence on HR (even the physiological one), or conversely enhance this dependence. Such an approach allows us to explore the HR contribution to the clinical significance of HRV, i.e. whether HR or its variability plays a main role in the HRV clinical value. This Research Topic covers recent advances in the application of HRV, methodological issues, basic underlying mechanisms as well as all aspects of the interaction between HRV and HR.
A poignant and inspirational love story set in Burma, The Art of Hearing Heartbeats spans the decades between the 1950s and the present. When a successful New York lawyer suddenly disappears without a trace, neither his wife nor his daughter Julia has any idea where he might be…until they find a love letter he wrote many years ago, to a Burmese woman they have never heard of. Intent on solving the mystery and coming to terms with her father’s past, Julia decides to travel to the village where the woman lived. There she uncovers a tale of unimaginable hardship, resilience, and passion that will reaffirm the reader’s belief in the power of love to move mountains.
The bestselling author of Intern and Doctored tells the story of the thing that makes us tick For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As the cardiologist and bestselling author Sandeep Jauhar shows in Heart: A History, it was only recently that we demolished age-old taboos and devised the transformative procedures that have changed the way we live. Deftly alternating between key historical episodes and his own work, Jauhar tells the colorful and little-known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ. He introduces us to Daniel Hale Williams, the African American doctor who performed the world’s first open heart surgery in Gilded Age Chicago. We meet C. Walton Lillehei, who connected a patient’s circulatory system to a healthy donor’s, paving the way for the heart-lung machine. And we encounter Wilson Greatbatch, who saved millions by inventing the pacemaker—by accident. Jauhar deftly braids these tales of discovery, hubris, and sorrow with moving accounts of his family’s history of heart ailments and the patients he’s treated over many years. He also confronts the limits of medical technology, arguing that future progress will depend more on how we choose to live than on the devices we invent. Affecting, engaging, and beautifully written, Heart: A History takes the full measure of the only organ that can move itself.
Open a Window into the Autonomic Nervous SystemQuantifying the amount of autonomic nervous system activity in an individual patient can be extremely important, because it provides a gauge of disease severity in a large number of diseases. Heart rate variability (HRV) calculated from both short-term and longer-term electrocardiograms is an ideal win