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In 1986, after the disastrous accident at the Union Carbide plant in Bhopal, Congress passed the Emergency Planning and Community Right-To-Know Act. Under this act, many business facilities became subject to new reporting requirements with respect to the presence of hazardous substances. Hadden, an associate professor at the Lyndon B. Johnson School of Public Affairs, conducted surveys relating to this act.
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.