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"Reflecting the innovative work of the Copenhagen Polis Centre's 2004 inventory of Archaic and Classical Greek city-states, Hansen's "shotgun method" for reconstructing and estimating the overall size and local distribution of the Greek population challenges the long-standing opinion that the majority of ancient Greeks lived a rural, subsistent life"--Provided by publisher.
Robert Churchill wrote the definitive book on instinctive wingshooting for game birds and sporting clays. It quickly became a classic in the field. Friend and collaborator Macdonald Hastings, himself a renowned shooting coach, twice revised and updated Churchill's book.
Sporting clay shooters are constantly striving for consistency. Move, Mount, Shoot describes the maintained lead method, an easily learned technique which will help both novice and expert alike achieve spectacular results. The book also examines the importance of mental preparation, . and includes advice on choosing a gun and equipment. Move, Mount, Shoot is the only comprehensive manual of this winning technique.
A timely book for DNA researchers, Automated DNA Sequencing and Analysis reviews and assesses the state of the art of automated DNA sequence analysis-from the construction of clone libraries to the developmentof laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that allows them to be compared and contrasted. By taking a broad view of the process of automated sequence analysis, the present volume bridges the gap between the protocols supplied with instrument and reaction kits and the finalized data presented in the research literature. It will be an invaluable aid to both small laboratories that are interested in taking maximum advantageof automated sequence resources and to groups pursuing large-scale cDNA and genomic sequencing projects. The field of automation in DAN sequencing and analysis is rapidly moving, this book fulfils those needs, reviews the history of the art and provides pointers to future development.
PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.
In this book, the latest tools available for functional metagenomics research are described.This research enables scientists to directly access the genomes from diverse microbial genomes at one time and study these “metagenomes”. Using the modern tools of genome sequencing and cloning, researchers have now been able to harness this astounding metagenomic diversity to understand and exploit the diverse functions of microorganisms. Leading scientists from around the world demonstrate how these approaches have been applied in many different settings, including aquatic and terrestrial habitats, microbiomes, and many more environments. This is a highly informative and carefully presented book, providing microbiologists with a summary of the latest functional metagenomics literature on all specific habitats.
Instructional book on shotgun skills for sporting clays and fieldcraft. Provides a better understanding for anyone to improve their performance and skills with a shotgun.
The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome. On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work. At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry.
• A solid guide for becoming a better shot • Wing shooting, sporting clays, skeet shooting • Expert teacher and coach shares years of experience Successful Shotgunning focuses on wing-shooting and sporting clays techniques. Gain a better understanding of the shooting process as a whole as you sharpen your skills and become a better shot. How to evaluate moving targets in wing-shooting situations in the field, in a competitive environment, on a sporting clays course, or on a skeet field. Choose the correct gun and gun fit for you; learn to diagnose some common eye problems and correct your aim; tame recoil; and deal with the challenges of various sporting clays targets. Quote from the book: "Successful shotgunning isn't an inherent trait, it is a skill and it must be learned like any other skill. It requires systematic study and the ability to accurately calculate the variables of moving targets. My coaching methods involve an intuitive technique that is based on pure logic and a systematic breakdown of all the variables involved. This is how the experts shoot. Over a period of time they build up a personal mental repertoire of sight pictures, which they can then successfully apply to each target, regardless of whether it is a quail, dove, duck or clay target. They then have the ability to see a subtle but consequential target/barrel relationship on every shot and adjust to each different shooting situation."