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The Neurobiology of C. elegans assembles together a series of chapters describing the progress researchers have made toward solving some of the major problems in neurobiology with the use of this powerful model organism. The first chapter is an introduction to the anatomy of the C. elegans nervous system. This chapter provides a useful introduction to this system and will help the reader who is less familiar with this system understand the chapters that follow. The next two chapters on learning, conditioning and memory and neuronal specification and differentiation, summarize the current state of the C. elegans field in these two major areas of neurobiology. The remaining chapters describe studies in C. elegans that have provided particularly exciting insights into neurobiology.
The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.* Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Derived from the acclaimed online “WormAtlas,†C. elegansAtlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm†by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegansII monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.​ In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development ​
Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration - Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.