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Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction. Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Cell Surface Carbohydrate Chemistry is a collection of papers from a symposium of the same title held in San Francisco, U.S.A. on September 1-2, 1976. The book discusses cell biology and carbohydrates, particularly oligosaccharides that make up the glycoproteins and glycolipids in the cell membrane of normal neoplastic cells. One paper discusses the involvement of membranes in the biosynthesis of glycoproteins. One author also analyzes the glycoproteins from the surface of tumor cells. The glycoproteins have complex saccharide structures similar to virus transformed fibroblasts or transformed epithelial cells. Another paper cites the concepts made by Abercrombie and Ambrose regarding distinct galactosyltransferase activity released by tumor cells. Another paper addresses a hypothetical mechanism to explain the control of cell growth by nucleoside efflux through the membrane. One author analyzes the basis for the selectivity of some cancer chemotherapeutic agents—these can also have an effect in the immunity responses of the host against cancer cells. This book can prove useful for the medically-oriented investigator, the biologist, and the scientist involved in molecular chemistry and cancer research.
This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.
Contributors to this volume explore the role of carbohydrates in communication between cells of multicellular organisms. Topics covered include the thermodynamics and spatial restrictions of oligosaccharide-protein interactions, the role of carbohydrates in recognition and as components of cell adhesion molecules, and abnormal glycosylation in several disease states.