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A majority of evolutionary biologists believe that we now can envision our biological predecessors--not the first, but nearly the first, living beings on Earth. This book is about these vanished forebears. The era between the first rudimentary life on Earth and the appearance of more complex beings is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers a glimpse into our ancient predecessors. To describe early RNA creatures, here called "ribocytes" or RNA cells, the author uses basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and more. Courting controversy among those who question the role of ribocytes -- citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus -- he offers a vision of early life on Earth.
"A Subject Collection from Cold Spring Harbor Perspectives in Biology."
A dual biography of Joan Steitz and Jennifer Doudna, two women who combined successful home lives with successful careers in science.
This book provides concise and cutting-edge reviews in astrobiology, a young and still emerging multidisciplinary field of science that addresses the fundamental questions of how life originated and diversified on Earth, whether life exists beyond Earth, and what is the future for life on Earth. Readers will find coverage of the latest understanding of a wide range of fascinating topics, including, for example, solar system formation, the origins of life, the history of Earth as revealed by geology, the evolution of intelligence on Earth, the implications of genome data, insights from extremophile research, and the possible existence of life on other planets within and beyond the solar system. Each chapter contains a brief summary of the current status of the topic under discussion, sufficient references to enable more detailed study, and descriptions of recent findings and forthcoming missions or anticipated research. Written by leading experts in astronomy, planetary science, geoscience, chemistry, biology, and physics, this insightful and thought-provoking book will appeal to all students and scientists who are interested in life and space.
This book introduces a fresh perspective on the conditions for the genesis of the first cell. An important possible environment of the prehistoric Earth has long been overlooked as a host to the perfect biochemical conditions for this process. The first complexes of continental crust on the early Earth must have already contained systems of interconnected cracks and cavities, which were filled with volatiles like water, carbon dioxide and nitrogen. This book offers insights into how these conditions may have provided the ideal physical and chemical setting for the formation of protocells and early stages of life. The authors support their hypothesis with a number of astonishing findings from laboratory experiments focusing on a variety of organic compounds, and on the formation of key cellular ingredients and of primitive cell-like structures. Moreover, they discuss the principles of prebiotic evolution regarding the aspects of order and complexity. Guiding readers through various stages of hypotheses and re-created evolutionary processes, the book is enriched with personal remarks and experiences throughout, reflecting the authors' personal quest to solve the mystery surrounding the first cell.
While the study of viral evolution has developed rapidly in the last 30 years, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book intends to fill this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.
Takes the reader through the origins of catalysis in RNA and necessarily includes significant discussion of structure and folding. The main focus of the book concerns chemical mechanism with extensive comment on how, despite the importance of RNA catalysis in the cell, its origins are still poorly understood and often controversial. The reader is given an outline of the important role of RNA catalysis in many aspects of cell function, including RNA processing and translation.