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How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness
The studies described here were carried out in the Neuroregul ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the last decade, this group, in close collaboration with the Department of Neurosurgery of the Academic Hospital of Leiden, has studied the development of the central nervous system from a neuroanatomical as well as a clinical perspective. During this period, the expression of several morphore gulators in the developing rat spinal cord was extensively investigated. Parallel studies focused on the development of the spinal cord fiber systems, which was studied by means of the intrauterine use of neuronal tracers. The main goal of these studies was to extend our knowledge about the (normal) generation of the spinal cord and to contribute to the under standing of clinical problems related to regeneration and degeneration in the mammalian central nervous system. The studies on morphoregulators, in particular, appeared to benefit two different scientific areas. Firstly, the correlation between morphoregulator expression patterns and known anatomy contributed to our knowledge about spinal cord development. Secondly, the correlation between morpho regulator expression patterns and known developmental processes may help to understand their precise function(s). This volume of Advances in Anatomy, Embryology and Cell Biology presents these particular studies on the development of the rat spinal cord performed over the last decade. As well as integrating the results of the tracer studies, this volume also provides an update on the development of the rat spinal cord.
The studies described here were carried out in the Neuroregulation Group at the Department of Physiology of the University of Leiden. Over the last decade this group has, in close collaboration with the departments of neurosurgery and urology of the Academic Hospital of Leiden, studied development and regeneration of the spinal cord and its peripheral nerves both from a neuroanatomical and a clinical perspective. During this period the development of brainstem projections to the spinal cord of the rat was studied with a retrograde tracing technique. Horseradish peroxidase was injected into the spinal cord of rat fetuses, both at different ages, and at different levels of the spinal cord. These studies aimed to discover regularities in the behavior of descending fiber systems that could yield insight into the logic that the nervous system must employ to structure its connectional pattern during development. Such insight might then be applied to improve regeneration of the nervous system.
This long-awaited update of the classic, The Human Nervous System, stands as an impressive survey of our knowledge of the brain, spinal cord, and peripheral nervous system. The book has been completely redone and brought up-to-date. An impressive and respected cast of international authors have contributed 37 chapters on topics ranging from Brain Evolution, all phases of Brain Development, to all areas of the adult brain and peripheral pathways, along with careful descriptions of the spinal cord and peripheral nervous system, brainstem and cerebellum. The Human Nervous System, Second Edition will again serve as the gold standard, providing a one-stop source of up-to-date information about our knowledge of the human nervous system.This second edition of the standard reference on the human nervous system is extensively and completely revised and updated from the 1990 first edition. Written by the leading researchers, many chapters have been completely rewritten, new chapters have been added. A new section on Evolution and Development provides a broader perspective, and all chapters include references and perspectives to neurological disease.
The core of this book is an atlas of the rat brain viewed from 73 representative transverse levels along its longitudinal axis. New to this edition is a second drawing of gray and white matter distribution that illustrates major features of gray matter regionalizion in a color-coded way that is carried through the flatmaps of the rat CNS and the hierarchical nomenclature tables. Computer graphics files of the atlas and flatmaps are provided on the CD-ROM. They can be used to learn more about the structure of the brain, to map experimental results on standard or reference templates, to form databases of spatial information about the rat brain, and to create 3-D models.
This unique text relates the dramatic advances of modern neurobiology to our understanding of the structure and function of the autonomic nervous system, providing a clear view of the central neuronal components involved in autonomic control. The scope is wide, ranging from anatomical pathways and molecular pharmacology to the perceptual qualities of autonomic sensation and their potential in modifying behavior. Essential background information is reviewed and the most recent research discussed in a readable, informative manner. The text is richly illustrated. The first six chapters offer a comprehensive review of the system's anatomy, physiology, and pharmacology, emphasizing the organization and control of the autonomic preganglionic neurons and the complexity of central pathways. Later chapters review the autonomic control of cardiovascular, sexual, urinary, endocrine, and other functions. Written by an international group of distinguished scientists, this work is a valuable resource for clinicians, scientists, and graduate students in the fields of anatomy, physiology, pharmacology, and neuroscience.
CNS Neurotransmitters and Neuromodulators: Dopamine is an indispensable single-volume resource for any researcher involved with dopamine in the central nervous system (CNS). Part of the CNS Neurotransmitters and Neuromodulators Series, it is destined to be the definitive reference work on this topic. This book is comprised of independently authored chapters dealing with biochemistry, molecular biology and localization of dopamine receptors and transporters, receptor interactions, growth factors, new antipsychotic drugs, and the neuroendocrinal and retinal functions of dopamine. The authors, an international group of well-known researchers from varied disciplines, have utilized the most up-to-date material in preparing their reviews. CNS Neurotransmitters and Neuromodulators: Dopamine is the perfect source for established researchers seeking the latest information or for students requiring an in-depth one-step introduction.
This book is the outcome of a decade of research on the neu roanatomical mechanisms of learning in the young laboratory rat. It is essentially a discourse on the functional organization of the brain in relation to problem-solving ability and intelli gence. During the period between 1980 and 1989, well over 1000 weanling albino rats were subjected to localized brain damage (or sham operations in the case of the controls) under deep anesthesia and aseptic surgical conditions, were allowed tore cover, and subsequently were tested on a wide variety of prob lems designed to measure general learning ability. Since vir tually every part of the brain rostral to the medulla has been explored with lesions, it has become possible not only to map a number of "putative" brain systems underlying the acquisition of distinctive problem-solving tasks, but to isolate several neu roanatomical mechanisms that appear to be selectively in volved in the acquisition of particular kinds of goal-directed learned activities. Of particular interest was the discovery of a "nonspecific mechanism" (previously referred to in our re search reports as the "general learning system") inhabiting the interior parts of the brain. One objective of this volume was to make these maps available in a single source. Another was to provide a descrip tion of learning syndromes arising from local lesions to differ ent parts of the brain.