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This book provides an interdisciplinary, integrative overview of environmental problem-solving using mild reaction conditions, green reagents, waste free and energy efficient synthesis in both industry and academic world. Discussions include a broad, integrated perspective on sustainability, integrated risk, multi-scale changes and impacts taking place within ecosystems worldwide. Features: This book serves as a reference book for scientific investigators who need to do greener synthesis of organic compounds, drugs and natural products under mild reaction condition using green reagents, eco-friendly catalysts and benign reaction mediums over traditional synthetic processes which is a key driving force of scientists. Greener synthesis of multiple value-added heterocycles opens up a new horizon towards the organic catalysis and for this purpose, development of natural resources acts as an effective catalyst. Using environmentally friendly reaction medium e.g. ACC, WETSA, WEBSA have been used for the synthesis of some crucial heterocyclic scaffolds such as bisenols and 2-amino-4H-pyrans, tetraketones, pyrans, and biaryls. This book can also be used as a textbook for graduate and post graduate level courses for students. Furthermore, the problems with answers in book will add better understanding for students.
The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.
Complete with problems and solutions, this book is written for advanced graduate and undergraduate students to expose them to a variety of strategies for the synthesis of organic compounds. This is done largely within the context of natural products synthesis, but includes some unnatural products synthesis. Multiple approaches to each group of synthesis targets are presented, and the approaches are compared with one another with an eye on similarities and differences. General problems in organic synthesis (for example, strategies for the preparation of 6-membered rings and 5-membered rings, the importance of oxidation state, the problem of acyclic diastereoselectivity, the problem of controlling absolute stereochemistry, the importance of functional group relationships) are introduced early in the book and revisited throughout the text within the context of a variety of structurally unrelated natural products. The book includes power-point presentations to provide teachers who do not (or do) specialize in organic synthesis with access to well-organized material they can use in the classroom (with advanced students). The book provides the reader with a somewhat historical overview of organic and natural products chemistry, and spans synthetic methodology that dates from the 1940's to present time. It is written in a style that readers will find entertaining at times. It also contains lots of useful references with complete titles provided. This is much more helpful to the reader than the usual author-journal-year-page information.
Explaining methods for carrying out chemical syntheses without the use of catalysts, this book shows how avoiding catalysts during synthesis can mean less use of toxic chemicals, environmentally damaging chemicals, or endangered elements, and lower costs.
Emphasises on contemporary applications and an intuitive problem-solving approach that helps students discover the exciting potential of chemical science. This book incorporates fresh applications from the three major areas of modern research: materials, environmental chemistry, and biological science.
Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals. Practical Organic Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include: safety in the laboratory environmentally responsible handling of chemicals and solvents crystallisation distillation chromatographic methods extraction and work-up structure determination by spectroscopic methods searching the chemical literature laboratory notebooks writing a report hints on the synthesis of organic compounds disposal and destruction of dangerous materials drying and purifying solvents Practical Organic Synthesis is based on a successful course in basic organic chemistry laboratory practice which has run for several years at the ETH, Zurich and the University of Berne, and its course book Grundoperationen, now in its sixth edition. Condensing over 30 years of the authors’ organic laboratory teaching experience into one easy-to-read volume, Practical Organic Synthesis is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists.
Provides an in-depth study of organic compounds that bridges the gap between general and organic chemistry Organic Chemistry: Concepts and Applications presents a comprehensive review of organic compounds that is appropriate for a two-semester sophomore organic chemistry course. The text covers the fundamental concepts needed to understand organic chemistry and clearly shows how to apply the concepts of organic chemistry to problem-solving. In addition, the book highlights the relevance of organic chemistry to the environment, industry, and biological and medical sciences. The author includes multiple-choice questions similar to aptitude exams for professional schools, including the Medical College Admissions Test (MCAT) and Dental Aptitude Test (DAT) to help in the preparation for these important exams. Rather than categorize content information by functional groups, which often stresses memorization, this textbook instead divides the information into reaction types. This approach bridges the gap between general and organic chemistry and helps students develop a better understanding of the material. A manual of possible solutions for chapter problems for instructors and students is available in the supplementary websites. This important book: • Provides an in-depth study of organic compounds with division by reaction types that bridges the gap between general and organic chemistry • Covers the concepts needed to understand organic chemistry and teaches how to apply them for problem-solving • Puts a focus on the relevance of organic chemistry to the environment, industry, and biological and medical sciences • Includes multiple choice questions similar to aptitude exams for professional schools Written for students of organic chemistry, Organic Chemistry: Concepts and Applications is the comprehensive text that presents the material in clear terms and shows how to apply the concepts to problem solving.