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We are swamped with information and each day seems to bring new discoveries that must be considered. Never before in the history of science have so many scientists been as active as today. It has become a major problem for the expert just to keep up with the literature in his or her own field of research. Why, then, should experts and their poor students worry about the pioneers of microbiology, those half-forgotten scientists who a century ago devoted their lives to a new science that was on its way to revolutionizing medicine?With so many new facts and problems screaming for our attention, it is easy to lose sight of the long road that we have travelled in order to get to the point where we are now. Tracing the path of those who have gone before us will help us to see our own scientific goals and efforts in a more revealing perspective.The great figures who are at the center of interest in this book — Robert Koch, Emil von Behring, Paul Ehrlich and Elie Metchnikoff — were far from uncontroversial during their lifetimes. It is interesting to see how they were judged by their peers at the Karolinska Institutet when they were considered for the Nobel Prize.Pioneers of Microbiology and the Nobel Prize has been written in such a way that it can be enjoyed even without an extensive knowledge of microbiology and medicine. In fact, a considerable part of the book portrays the state of medicine during the middle of the 19th century, when bacteriology can be said to have made its debut on the medical scene.
The Nobel Prizes m natural sciences have achieved the reputation of being the ultimate accolade for scientific achievements. This honk gives a unique insight into the selection of Nobel Prize recipients, in particular the life sciences. The evolving mechanisms of selection of prize recipients are illustrated by reference to archives, which have remained secret for 1) years. Many of the prizes subjected to particular evaluation concern awards given for discoveries in the field of infectious diseases and the interconnected field of genetics. The book illustrates the individuals and environments that are conducive to scientific creativity. Nowhere is this enigmatic activity'-- the mime mover in advancing the human condition highlighted as lucidly as by identification individuals worthy of Nobel Prizes. --Book Jacket.
Physiology or medicine was the third prize area Alfred Nobel mentioned in his will. Nobel had an active interest in medical research. He came into contact with Swedish physiologist Jöns Johansson through Karolinska Institute around 1890. Johansson worked for a brief period in Nobel's laboratory in Sevran, France during the same year. The Nobel Prize in Physiology or Medicine is awarded by the Nobel Assembly at Karolinska Institute. This volume is a collection of the Nobel lectures delivered by the Nobel Laureates, together with their biographies and the presentation speeches for the period 2006-2010.List of Laureates and their award citations:(2006) Andrew Z Fire and Craig C Mello — for their discovery of RNA interference-gene silencing by double-stranded RNA;(2007) Mario R Capecchi, Martin J Evans and Oliver Smithies — for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells;(2008) Harald zur Hausen — for his discovery of human papilloma viruses causing cervical cancer, and Françoise Barré-Sinoussi and Luc Montagnier — for their discovery of human immunodeficiency virus;(2009) Elizabeth H Blackburn, Carol W Greider and Jack W Szostak — for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase;(2010) Robert G Edwards — for the development of in vitro fertilization.
This book is a must not only for neuroscientists and historians but also for physicians all around the world who are interested in the history of medicine, the Karolinska Institute, and the two Swedish contemporaries Axel Key and Alfred Nobel. It provides enjoyable and informative reading, and, with a large number of portraits, it puts faces to the nerves, cells, microbes and diseases that have been named after their famous discoverers.
Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering the current state of a particular field and future directions. New chapters in the updated volume include A Tour de Force: The Discovery, Properties, and Function of Piezo Channels, Piezo1 Channels in Vascular Development and the Sensing of Shear Stress, the Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels, Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction, and The Structural Basis for Sensing by the Piezo1 Protein. Users of this series will find an up-to-date presentation of the current knowledge in the field of Piezo Channels. - Written by leading experts in the field - Contains original material, both textual and illustrative, that make it a very relevant reference - Presented in a very comprehensive manner - Ideal reference for both researchers in the field and general readers who will find this book to be relevant and up-to-date
The present book discusses the Nobel Prizes in physiology or medicine 1966-68. The 1966 prize recognized that viruses may be involved in cancer formation. Later studies revealed that these kinds of infectious agents could pick up and transmit cellular genes of importance for regulation of cellular growth. It was then possible to recognize that many genes of this kind could be involved in the formation of cancer. The disease was found to represent the dark side of evolution. As a consequence of this insight new means of treatment fortunately have been developed.The rear parts of the eyes are extensions of the central nervous system. They have a fascinating intrinsic complexity, the neurophysiology and biochemistry of which has been progressively analyzed. These revealing studies concern both our capacity to distinguish different colors and also our possibility to see in the dark. The Prize in 1967 identified seminal contributions in this wide field by Ragnar Granit, Haldan Hartline and George Wald.The 1968 Prize is distinct in its recognition of Robert Holley, Ghobind Khorana and Marshall Nirenberg, who in different ways had contributed to the cracking of the genetic code. Insights into the language used by Nature, since the dawn of cellular life some 4.6 billion years ago, have completely revolutionized modern life sciences. The capacity to read and also to write the books of life has defined new kinds of science, deepening our understanding of the magic of evolution and opened the possibilities for molecular medicine by understanding the genetic background to diseases, not least cancer.Related Link(s)
This invaluable book contains 36 interviews, including 26 with Nobel laureates. It presents a cross-section of biomedical science, a field that has been dominant in science for the past half century. The in-depth conversations cover important research areas and discoveries, as well as the roads to these discoveries, including aspects of the scientists' work that never saw publication. They also bring out the humanness of the famous scientists — the reader learns about their backgrounds, aspirations, failings, and triumphs. The book is illustrated with snapshots of the conversations and photos provided by the interviewees. It is a follow-up to the critically acclaimed Candid Science: Conversations with Famous Chemists, by the same author./a
In The Beginner's Guide to Winning the Nobel Prize, Doherty recounts his unlikely path to becoming a Nobel Laureate. Beginning with his humble origins in Australia, he tells how he developed an interest in immunology and describes his award-winning, influential work with Rolf Zinkernagel on T-cells and the nature of immune defense. In prose that is at turns amusing and astute, Doherty reveals how his nonconformist upbringing, sense of being an outsider, and search for different perspectives have shaped his life and work. Doherty offers a rare, insider's look at the realities of being a research scientist. He lucidly explains his own scientific work and how research projects are selected, funded, and organized; the major problems science is trying to solve; and the rewards and pitfalls of a career in scientific research. For Doherty, science still plays an important role in improving the world, and he argues that scientists need to do a better job of making their work more accessible to the public. Throughout the book, Doherty explores the stories of past Nobel winners and considers some of the crucial scientific debates of our time, including the safety of genetically modified foods and the tensions between science and religion. He concludes with some "tips" on how to win a Nobel Prize, including advice on being persistent, generous, and culturally aware, and he stresses the value of evidence. The Beginner's Guide to Winning the Noble Prize is essential reading for anyone interested in a career in science.
Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.