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The very rapid pace of advances in biomedical research promises us a wide range of new drugs, medical devices, and clinical procedures. The extent to which these discoveries will benefit the public, however, depends in large part on the methods we choose for developing and testing them. Modern Methods of Clinical Investigation focuses on strategies for clinical evaluation and their role in uncovering the actual benefits and risks of medical innovation. Essays explore differences in our current systems for evaluating drugs, medical devices, and clinical procedures; health insurance databases as a tool for assessing treatment outcomes; the role of the medical profession, the Food and Drug Administration, and industry in stimulating the use of evaluative methods; and more. This book will be of special interest to policymakers, regulators, executives in the medical industry, clinical researchers, and physicians.
A book about SURVIVING Some of the Deadliest Plagues Known to Humanity... (& An Antidote to Corona Virus/COVID-19?) “…the more you know about the past, the better you are prepared for the future.” ~ Theodore Roosevelt ~ The direct quotes given throughout this study - augmented by original mortality data compiled and edited by A. Parent, reveals a lesser-known history of the dramatic decline in deaths from a whole plethora of pathogens that once plagued our developing nations and its probable cause. I.e., a natural universal biological phenomenon of ancestrally acquired robust resilience to dying from once deadlier contagions throughout the generations. The significance of this being that, whilst our health officials are expecting the plagues of old to return at any moment and are poised nervously armed with whatever vaccines they can throw at them, it would appear that our immune systems having very long-term ancestral memory have not forgotten how to battle against such opportunistic invaders of the past and it now looks highly likely that almost all of us would survive even if some of the deadliest contagions returned today to plague us in their original colours. This, therefore, also has implications for our more modern and firmly entrenched belief that we eradicated at least some of these bugs and, obviously, with our current mass vaccination strategies that are so firmly entrenched and becoming near-universal, we are not currently following nature's schedule of childhood natural immunization as a result. Thus, we assess the consequences of this situation in the context of the above. In essence, after reviewing all the relevant evidence for when, how and to what degree we have attempted to protect against infectious diseases at a population level versus nature's method of full exposure, this study reaches the inescapable conclusion that Nature has done a significantly better job of natural mass immunization down through the generations and across the entire world in line with our respective levels of development, a whole lot better than us. The moral of this story is that it looks like our ancestors were counting more of their descendent children (that's us) because they had the (actual) Pox and just about everything else going in the way of infectious diseases and we were healthier as a result. That was until we began to intervene in the natural generational immunity cycle - but, the protection afforded by our mass vaccination efforts being so short-lived - ironically, maybe helping to restore this remarkable immunization cycle once again. All in all, it is hoped that this study will go some way to alleviating our unnatural phobia regarding the germ or pathogens of old returning, and go some way to restoring our faith in Nature so that this may inform a more natural health focused future.
The “essential” companion to the landmark Users' Guides to the Medical Literature - completely revised and updated! 5 STAR DOODY'S REVIEW! "This second edition is even better than the original. Information is easier to find and the additional resources that will be available at www.JAMAevidence.com will provide readers with a one-stop source for evidence-based medicine."--Doody's Review Service Evidence-based medicine involves the careful interpretation of medical studies and its clinical application. And no resource helps you do it better-and faster-than Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice. This streamlined reference distills the most clinically-relevant coverage from the parent Users' Guide Manual into one highly-focused, portable resource. Praised for its clear explanations of detailed statistical and mathematical principles, The Essentials concisely covers all the basic concepts of evidence-based medicine--everything you need to deliver optimal patient care. It's a perfect at-a-glance source for busy clinicians and students, helping you distinguish between solid medical evidence and poor medical evidence, tailor evidence-based medicine for each patient, and much more. Now in its second edition, this carry-along quick reference is more clinically relevant--and more essential--than ever! FEATURES Completely revised and updated with all new coverage of the basic issues in evidence-based medicine in patient care Abundant real-world examples drawn from the medical literature are woven throughout, and include important related principles and pitfalls in using clinical research in patient care decisions Edited by over 60 internationally recognized editors and contributors from around the globe Also look for JAMAevidence.com, a new interactive database for the best practice of evidence based medicine.
Nanotechnological Applications in Virology explores the use of nanoparticles-based technologies to fight against viruses, also discussing the use of nanoparticles in the preparation of nano masks and as sanitizing agents. The role of nanotechnology against HIV, Hepatitis, Influenza, Herpes, Ebola and Zika using rapid detection and diagnostic techniques is included, as is a brief description of SARS, MERS, the novel Coronavirus, and recent advancements in its treatment process. Other sections cover the formulation of novel nano-vaccines for the treatment and control of viral infections like HIV, Hepatitis and COVID-19. Included toxicological studies of nanoparticles provide readers with a brief overview on global scenarios regarding viral infections. Nanotechnology is the present age technology, with wide usage in different areas of medical science, including drug delivery, gene therapy, antimicrobials, biosensors and bio-labelling. Nanoparticles play a competent role as an anti-infection agent and thus act as efficient antiviral agents. - Mitochondria as a Key Intracellular Target of Thallium Toxicity presents a new hypothesis that explains the decrease in antioxidant defense in thallium poisoning. In addition, the book proposes a new model for studying the transport of inorganic cations across the inner mitochondrial membrane. Readers will learn about the toxicity of thallium and its compounds, the toxicology of thallium, the toxic thallium effects on cells, and the effects of thallium on mitochondria. This book+J136 lists the pathways and mechanisms of thallium transport into cells and mitochondria. This toxicity has been analyzed at both the cellular and subcellular levels - The increase in human contact with the toxic trace element thallium is associated with developments in industry, the release of this metal into the environment from various rocks, and the use of special isotope techniques for studying the vascular bed
Advances in Clinical Chemistry
Presents 12,860 entries listing scholarly publications on Greek studies. Research and review journals, books, and monographs are indexed in the areas of classical, Hellenistic, Biblical, Byzantine, Medieval, and modern Greek studies., but no annotations are included. After the general listings, entries are also indexed by journal, text, name, geography, and subject. The CD-ROM contains an electronic version of the book. Annotation copyrighted by Book News, Inc., Portland, OR