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The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues, and operational issues. This current, practical reference also reviews such critical areas as strategic planning, data center management, data center controls, systems planning, network technology, contingency planning, human resource planning, desktop computing, and future directions. The Enterprise Operations Management Handbook serves as an invaluable tool for designing, building, and maintaining a high-performance, service-oriented data center.
The Enterprise Operations Management Handbook provides the expert advice and guidance of hundreds of leading computing practitioners and consultants. Covering all major areas of enterprise operations management, this edition provides essential information for managing a modern, evolving data center. Topics include business issues, technology issues, and operational issues. This current, practical reference also reviews such critical areas as strategic planning, data center management, data center controls, systems planning, network technology, contingency planning, human resource planning, desktop computing, and future directions. The Enterprise Operations Management Handbook serves as an invaluable tool for designing, building, and maintaining a high-performance, service-oriented data center.
Dependability and cost effectiveness are primarily seen as instruments for conducting international trade in the free market environment. These factors cannot be considered in isolation of each other. This handbook considers all aspects of performability engineering. The book provides a holistic view of the entire life cycle of activities of the product, along with the associated cost of environmental preservation at each stage, while maximizing the performance.
A unique comparison of the theory and practice of corporate and individual sanctions applied in competition law across five continents.
Procedure Manual for the Diagnosis of Intestinal Parasites is the definitive resource for individuals involved in the collection, preparation, and examination of fecal specimens for microscopic diagnosis of intestinal parasitic infections. The book points out the stages of parasites possibly found in a fecal specimen, how to find them, and how to identify them. Specific details on how to effectively use the microscope for parasitic diagnosis are included. This information is missing from most texts and manuals of this kind. Photomicrographs and original drawings of the various stages and forms of parasites and eggs are used extensively throughout the text, with the photomicrographs printed to a standard scale for easy comparison. More than 400 illustrations in all are included. Biological keys for intestinal amoebae and eggs of various species of helminths are provided. This book is an essential reference for teachers of diagnostic parasitology and their students, physicians who order fecal examinations for intestinal parasites, nurses or health workers who handle or prepare the specimens for the laboratory, and technologists who receive, process, and examine the specimens.
Lists news events, population figures, and miscellaneous data of an historic, economic, scientific and social nature.
About the Book Beat the Devils is a memoir of the life of John R. David, which includes his research, discovering one of the first cytokines MIF (Migration Inhibitory Factor), a proinflammatory cytokine critical in autoimmunity and sepsis. John also worked on parasites affecting humans with new diagnostics and treatments. Read Beat the Devils and learn about John and his wife of 62 years, Roberta, working together; Lisa, his daughter, COO of Planned Parenthood and now CEO of Public Health Solutions; Joshua, his son, who started the High Line in NYC; John’s director father, who married Deana Durbin; how John sent 200,000 condoms twice to prevent HIV/AIDS at the Carnival in Salvador, Brazil; and much more. About the Author John R. David practices the piano for three hours a day and records duets with his wonderful composer/cellist/piano teacher, Andrea Casarrubios. John’s son and daughter live five minutes away and his two granddaughters, Nathalie and Claudia, are 25 minutes away, which he loves. He is a member of the National Academy of Medicine, American Academy of Arts and Science, and American Association of Immunologists. John attended Hollywood High School and the University of Chicago for college and medical school.