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For Val Haines, dying may be the chance of a lifetime. Awakening in a jail cell and bleeding from his head, Val Haines remembers nothing. Not even his name. As his memory slowly begins to return, Haines discovers that the world thinks he's dead. If his nightmares ring true, it may be for the best. Around him brews a conspiracy of embezzlement and murder for hire, fueled by the rage of personal vendetta. As he searches for a safe haven, enigmatic Audrey beckons, but can she be trusted? With nothing but a few personal belongings and a sizable amount of cash, Haines must run. With his past behind him, he'll do anything to claim a new life for himself. Or die trying.
For Val Haines, dying may be the chance of a lifetime. Awakening in a jail cell and bleeding from his head, Val Haines remembers nothing. Not even his name. As his memory slowly begins to return, Haines discovers that the world thinks he's dead. If his nightmares ring true, it may be for the best. Around him brews a conspiracy of embezzlement and murder for hire, fueled by the rage of personal vendetta. As he searches for a safe haven, enigmatic Audrey beckons, but can she be trusted? With nothing but a few personal belongings and a sizable amount of cash, Haines must run. With his past behind him, he'll do anything to claim a new life for himself. Or die trying.
The growth of the pharmaceutical industry over the past decade is astounding, but the impact of this growth on statistics is somewhat confusing. While software has made analysis easier and more efficient, regulatory bodies now demand deeper and more complex analyses, and pharmacogenetic/genomic studies serve up an entirely new set of challenges. For more than two decades, Statistics in the Pharmaceutical Industry has been the definitive guide to sorting through the challenges in the industry, and this Third Edition continues that tradition. Updated and expanded to reflect the most recent trends and developments in the field, Statistics in the Pharmaceutical Industry, Third Edition presents chapters written by experts from both regulatory agencies and pharmaceutical companies who discuss everything from experimental design to post-marketing studies. This approach sheds light on what regulators consider acceptable methodologies and what methods have proven successful for industrial statisticians. Both new and revised chapters reflect the increasingly global nature of the industry as represented by authors from Japan and Europe, the increasing trend toward non-inferiority/equivalence testing, adaptive design in clinical trials, global harmonization of regulatory standards, and multiple comparison studies. The book also examines the latest considerations in anti-cancer studies. Statistics in the Pharmaceutical Industry, Third Edition demystifies the approval process by combining regulatory and industrial points of view, making it a must-read for anyone performing statistical analysis at any point in the drug approval process.
This rewritten and updated second edition provides comprehensive information on the wide-ranging applications of statistics in the pharmacological field. Focusing on practical aspects, it sets out to bridge the gap between industry and academia.;Reflecting the changes that have taken place since publication of the first edition, this volume covers new topics such as: cancer clinical trials, clinical trials of AIDS patients and animal tumorigenicity studies; the development of antiepileptic drugs; the role of epidemiology in postmarketing trials and adverse drug experience; computer-assisted new drug application (CANDA) submissions; contract research organizations; interim analysis in clinical trials; and room-temperature tests for the stability of drugs.;This work is intended as: a reference for statisticians, biostatisticians, pharmacologists, administrators, managers, and scientists in the pharmaceutical industry; and a text for graduate students taking courses in applied statistics or pharmaceutical statistics.
The Lazarus Stone: The Evil Within takes readers on an action-packed thrill ride that begins over a thousand years ago and winds through the halls of todays Vatican. In a new twist on the supernatural and the immortal, a religious war thats raged for centuries is being fought by the Hunters and the Dark Ones. Bred during the time of the Crusades, the existence of these immortals is a dark secret the Vatican is trying desperately to hide. The last few Hunters work outside the law, fighting against the evil that the Vatican accidentally unleashed upon the world. In the Bible, Lazarus was raised by Gods hand. In this book, the stone upon which Lazarus arose absorbed Gods power and was found to have healing properties. In a time of need, the Vatican used the stone to raise its knights back from the dead, but there were unforeseen consequences. Readers will be glued until the final page. In their debut novel,
This new edition of Invasion Ecology provides a comprehensive and updated introduction to all aspects of biological invasion by non-native species. Highlighting important research findings associated with each stage of invasion, the book provides an overview of the invasion process from transportation patterns and causes of establishment success to ecological impacts, invader management, and post-invasion evolution. The authors have produced new chapters on predicting and preventing invasion, managing and eradicating invasive species, and invasion dynamics in a changing climate. Modern global trade and travel have led to unprecedented movement of non-native species by humans with unforeseen, interesting, and occasionally devastating consequences. Increasing recognition of the problems associated with invasion has led to a rapid growth in research into the dynamics of non-native species and their adverse effects on native biota and human economies. This book provides a synthesis of this fast growing field of research and is an essential text for undergraduate and graduate students in ecology and conservation management. Additional resources are available at www.wiley.com/go/invasionecology
Plunged back into the enchanting yet perilous realm of Empire, Gwin finds herself at the forefront, battling not only for her survival but also for the lives of her companions. Cast into a treacherous world vastly different from her own, this novice commander faces the daunting task of moulding a disparate group of outcasts into a cohesive fighting force. United in their cause, they confront a brutal adversary, unravel a deadly plot, and seek to amend a grave injustice. This gripping tale is a blend of courage, intrigue, and the unyielding pursuit of justice, as Gwin and her warband navigate the tumultuous and violent landscape of the Empire.
Take a moment and examine your life in this instant. Ponder and think honestly about what you have overcome throughout the struggles in your life. Glimpse at the reality; you managed to walk away from the experience you went through with only a few wounds this day. They may be deep, and how you received them still lingers in your mind. Yet you are still standing. You survived the battle, and the worse is behind you. Now it is time to proceed to the future. Yet the past has returned with a vengeance and an undying thirst for revenge. It was not satisfied with how things had settled. No, you have to suffer more, hurt more, bleed more until you are nothing left but a shell of your former self. You bear the world’s anger toward you and fully succumb to its fury. But you won’t go down, no matter the odds, and you continue to be defiant to this day. The past will strike harder. You strategize your next step, counter the blows dealt, and you strike. Oh, you strike with the wrath to rival a god because you know you can’t falter. This is now a war, and like the battle before, you must overcome despite the odds. Because if you don’t, what was it all for? So fight for your existence or suffer extinction. This is the world of King of Kings. Every battle is the epitome of life or death, and the future you desire is on the line at every moment of your life.
The start of the American Revolution puts both Nicole and Anne in danger. A bestselling and award-winning historical series!
In a Time of Revolution, Even Hearts Can Be Overturned In England together at the Harrow estate, Anne and Nicole find themselves facing divergent futures. While Anne comfortably settles into British life, Nicole once again searches the far horizon. Despite the raging War of Independence, she sets sail for the American colonies to manage her uncle's landholdings. The gallant Captain Goodwind captures Nicole's attention, but not yet her heart. In the midst of revolution, her loyalties and faith are tested beyond what she could have ever imagined. Then she comes face to face with a staggering betrayal, and she is forced to choose her ultimate allegiance.