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Coping with modern technology in the life sciences (biology and medicine) became a major issue for people living in the Twentieth Century, and continues to be so in the present century. Biotechnology creates new opportunities and possibilities, but also new dangers, risks, and ethical concerns. In this volume, ethical dilemmas in the context of a specific biomedical technology are discussed. Experts in ethics, philosophy, psychoanalysis, and medicine jointly investigated a field of prenatal and genetic research that seems particularly challenging: prenatal diagnostics. In many European countries amniocentesis, for example, is a routine diagnostic tool for women becoming pregnant after the age of thirty-five. In recent decades, enormous progress has been made in diagnosing genetically-based diseases and other serious prenatal abnormalities. Today, we know that a positive prenatal genetic diagnostic creates distress for all women and their partners, and necessitates making the difficult decision as to whether or not to allow the pregnancy to continue. As is demonstrated in this volume through the summaries of interviews with couples, the reactions of women and their partners who are facing this situation can be very different. The new and innovative interdisciplinary dialogue on this topic that is presented in this volume offers a deeper understanding of the ethical dilemmas raised by prenatal and genetic diagnostics, and explores ways to support couples in this extremely difficult situation.
For Jones the establishment of a definitive relationship between individual and society is central to the development of both engaged Buddhism and sociology. Here he tells readers how to bridge their spiritual practice to social action.
This issue of Rheumatic Disease Clinics focuses on Genetics. Article topics cover: Genetic Influences on Susceptibility and Severity of Rheumatoid Arthritis; HLA-disease associations in rheumatoid arthritis; Autoinflammatory Syndromes as a Model of Monogenic Diseases; Genomic Influences on Hyperuricaemia and Gout; Genetics of Systemic Lupus Erythematosus; Genetics of Ankylosing Spondylitis;Genetics of Scleroderma; Genetics of Osteoarthritis; Genetics of Juvenile Inflammatory Arthritis; Genetic Influences on Treatment Response in Rheumatic Diseases; Integrative approaches/computational biology; Future directions of genetic research in rheumatic diseases; and Population genetics and natural selection in rheumatic disease.
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize
Together with Consulting Editor Dr. William Rayburn, Drs. D. Michael Nelson and Leslie Myatt have put together a unique issue that discusses The Human Placenta in Health and Disease. Expert authors have contributed clinical review articles on the following topics: Why obstetricians know the future health of the babies they deliver; How obstetricians can predict the future health of mothers after a complicated pregnancy; What obstetricians need to know about placental pathology; Immunology of the placenta; Diabetes mellitus, obesity, and the placenta; Intrauterine growth restriction and placental dysfunction; The placenta as the root cause for preeclampsia; Placental anatomy and function in twin gestations; Placental implantation disorders: accreta, previa, and abruptio placentae; Key infections in the placenta; Chorioamnion function in normal and abnormal pregnancy; The future for imaging modalities of the human placenta; Artificial reproductive technologies and the decidual and placental development interface; and When the fetus goes still and the birth is tragic: The role of the placenta in stillbirths. Readers will come away with the clinical information they need to improve outcomes in the women, mothers, and infants.
Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. - Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases - Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established - Provides stimulating discussions on developing new medical therapiesHighlights the importance of studying humans to understand mechanisms of disease that affect humans
Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis. - Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles - Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology - Delves into unanswered questions and future directions of this important blood-clotting complex