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Leverage your built-in rhythms of Upstates and Downstates to enhance energy, sharpen thinking, balance moods, fuel fitness, and more. If you’re like most people, the relentless daily grind of go-go-go, do-do-do, can run down your energy and deplete your resources. While most of us find our lives full of “Upstate” moments that rev up our stress engines, it doesn’t have to be this way. World-renowned sleep researcher Sara C. Mednick, PhD, shows us how we can access the most replenishing and repairing aspects of sleep through activities and moments that happen during our day by diving into our “Downstate.” Dr. Mednick shows that bringing ourselves back to the Downstate is critical for our health, well-being, and cognitive longevity. Drawing on her original findings—and those of others across many fields of medicine—Dr. Mednick creates a comprehensive picture of the Upstate/Downstate rhythms that orchestrate all of our bodies’ vital systems, along with a novel theory that aging is caused by spending less and less time in Downstate activities. The Power of the Downstate offers practical, evidence-based insight into how we can all enable those systems to work together in better harmony. You’ll learn: How our bodies and minds are guided by a natural Upstate/Downstate rhythm—and how our modern lifestyles disrupt these rhythms to our detriment; How our vital organs and systems benefit from spending more time in the Downstate – which decreases the risk for Alzheimer’s disease, chronic illness, and early death; How we can activate the Downstate through rethinking how to breathe, eat, sleep and exercise; and The practical four-week Downstate RecoveryPlus Plan. Get ready to be more alert, productive, and cognitively sharp during the day, feel greater intimacy and affection, and enjoy consolidated, restorative sleep at night . . . not to mention expand your years of mental and physical vitality.
This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It will assist these specialists in the diagnosis and treatment of steroid disorders. The book is written for postgraduate and faculty-level physicians. The content consists of steroid disorders, genetic bases for the disorder and case presentations of each disorder. Provides a common language for professionals to discuss and diagnose genetic steroid disorders Includes the very latest details on genetic tests and diagnoses Offers a strong understanding of the molecular basis for the diseases and therefore correct diagnosis and treatment of steroid disorders Presents insight into which medications to use based on the genetic makeup of a patient Teaches the best strategies and most effective use of genetic information in the patient counseling setting
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
"Why Low Carb Should Be the Default Approach for Managing and Preventing Metabolic Syndrome and Other Chronic Diseases. Almost every day it seems a new study is published that shows you are at risk for diabetes, cardiovascular disease, or all-cause mortality due to something you've just eaten for lunch. Many of us no longer know what to eat or who to believe. In the Nutrition Revolutiont; distinguished biochemist Richard Feinman, PhD, cuts through the noise, explaining the intricacies of nutrition and human metabolism in accessible terms. He lays out the tools you need to navigate the current confusion in the medical literature and its increasingly bizarre reflection in the media. At the same time, The Nutrition Revolution offers an unsparing critique of the nutritional establishment, which continues to demonize fat and refute the benefits of low-carbohydrate and ketogenic diets, all despite decades of evidence to the contrary. Feinman tells the story of the first low-carbohydrate revolution fifteen years ago, how it began, what killed it, and why a second revolution is now reaching a fever pitch. He exposes the backhanded tactics of a regressive nutritional establishment that ignores good data and common sense, and highlights the innovative work of those researchers who have broken rank. Entertaining, informative, and irreverent, Feinman paints a broad picture of the nutrition world: the beauty of the underlying biochemistry; the embarrassing failures of the medical establishment; the preeminence of low-carbohydrate diets for weight loss, diabetes, other metabolic diseases, and even cancer; and what's wrong with the constant reports that common foods represent a threat rather than a source of pleasure."--
Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.
"In the preface to this impressive and well-produced book, the editors state that their aim is not to describe a new surgical specialty, since most surgeons will soon need to be "geriatric surgeons," but to assemble a comprehensive account that will allow "all providers of healthcare to the elderly to understand the issues involved in choosing surgery as a treatment option for their patients." This is a useful book that deserves to do well. I hope that the editors and their publisher will have the stamina to make this the first of several editions, as it is clear that updated information about surgery in the elderly will be required to keep pace with this important field." NEJM Book Review