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General considerations; Tumors of the skin and soft tissues; Tumors of muscle; Tumors of bone and cartilage; Tumors of the lymphoid and hemopoietic tissues; Tumors of the respiratory system; Tumors of the alimentary tract; Tumors of the pancreas, liver, gall bladder, and mesothelium; Tumors of the urinary system; Tumors of the genital system; Tumors the mammary gland; Tumors of the endocrine gland; Tumors of the nervous system and eye.
As was shown in the first two volumes of this series, great strides have been made in identifying many of the agents or classes of substances responsible for carcinogenesis and in delineating their interactions with the cell. Clearly, the aim of such studies is that, once identified, these agents can be eliminated from the environment. Yet, despite these advances and the elimination of some important carcinogenic agents, one major problem exists. It is a constant monitor of all oncologic study and diminishes the importance of every experiment and of every clinical observation. As we noted earlier, that problem is our inability to define the malignant cell. It is through studies of the fundamental biology of tumors that we seek this definition. A vast amount of information has been gathered which describes what this cell does and-to a lesser extent-how it does it. But the why evades us. We have been unable to define the malignant cell, save in broad terms by comparing it to its normal counterpart. The major problem appears to be that the malignant cell does so much. It is a chimera, mystifyingly composed of normal activities and structures, of phenotypic schizophrenia with embryonic, fetal, and adult charac teristics and, occasionally, a hint of an unclassifiable capacity unique to malignant cells.
Pathology of Domestic Animals, Volume 1 elaborates on the bone structure and diseases, as well as the genital, circulatory, and respiratory systems, of domestic animals. The manuscript first offers information on bones, joints, and synovial structures and diseases of joints, including adaptational deformities of the skeleton, metabolic diseases of bones, necrosis and inflammation of bones, and discontinuities of bone and the healing of fractures. The text then ponders on the circulatory and respiratory systems. Discussions focus on congenital anomalies of the heart and large vessels, myocardium, hypertrophy and dilation of the heart, pharynx and guttural pouches, larynx and trachea, lungs, and pleura and mediastinum. The publication examines the haemopoietic system and endocrine glands. Topics include blood and bone marrow, general reactions of erythrocytes to injury, lymphoreticular tissues, adrenal glands and paraganglia, and polycythaemia. The book then reviews the male and female genital systems. The manuscript is a valuable source of data for readers interested in the pathology of domestic animals.
This fourth edition of the anthrax guidelines encompasses a systematic review of the extensive new scientific literature and relevant publications up to end 2007 including all the new information that emerged in the 3-4 years after the anthrax letter events. This updated edition provides information on the disease and its importance, its etiology and ecology, and offers guidance on the detection, diagnostic, epidemiology, disinfection and decontamination, treatment and prophylaxis procedures, as well as control and surveillance processes for anthrax in humans and animals. With two rounds of a rigorous peer-review process, it is a relevant source of information for the management of anthrax in humans and animals.
Laboratory Animal Medicine has made enor We deeply appreciate the efforts of each of the mous strides in the 47 years since R. Jaffe published authors and co-authors of the 23 chapters in this his "Anatomy and Pathology of Spontaneous Dis two volume work. In some instances the reader will eases of Small Laboratory Animals" in 1931. So note what appears to be repetition in certain chap ters. This repetition was allowed to stand in some much new information had accumulated that in a cases because different approaches seemed useful, new edition in 1958, Jaffe, aided by Cohrs and Meessen, needed the assistance of 46 colleagues to although efforts were made to delete most of the do the subject justice. Like its predecessor, this two redundancy which inevitably arises in a venture of volume comprehensive treatise on "Pathologie der this kind. We will be grateful if our colleagues point out errors and send us specific and general Laboratoriumstiere" was written in German and criticism of this work to allow corrections in the thus not readily available to the widening circle of event of reprinting or a next edition. veterinarians and pathologists who now are inter One objective has been to assemble current in ested in laboratory animals. Aside from the need to have a comprehensive formation in the pathologic aspects of diseases of review of laboratory animal pathology in English, laboratory animals.