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New discoveries reveal how crucial interactions which determine our destiny occur before birth, when our genes interact with their environment as the embryo and fetus develop. These processes - in the matrix of the womb - are evolutionary echoes of mechanisms which allowed our hunter-gatherer ancestors to survive. These exciting insights into predictive adaptive responses suggest new ways of protecting the health of the fetus, infant and adult. If inappropriate they can trigger obesity, diabetes and heart disease, formerly thought to result solely from adult lifestyle. The new concepts in this book are crucial to understanding the daunting public health burden in societies undergoing rapid transition from poverty to affluence. They add an important new dimension to evolutionary theory. Synthesising developmental biology, evolutionary history, medical science, public health and social policy, this is a ground-breaking and fascinating account by two of the world's leading pioneers in this important emerging field.
A ground-breaking and fascinating account of fetal origins of adult disease.
A valuable insight into fetal growth and development across all the main body systems.
The Atlas of Fetal and Neonatal Brain MR is an excellent atlas that fills the gap in coverage on normal brain development. Dr. Paul Griffiths and his team present a highly visual approach to the neonatal and fetal periods of growth. With over 800 images, you’ll have multiple views of normal presentation in utero, post-mortem, and more. Whether you’re a new resident or a seasoned practitioner, this is an invaluable guide to the new and increased use of MRI in evaluating normal and abnormal fetal and neonatal brain development. Covers both fetal and neonatal periods to serve as the most comprehensive atlas on the topic. Features over 800 images for a focused visual approach to applying the latest imaging techniques in evaluating normal brain development. Presents multiple image views of normal presentation to include in utero and post-mortem images (from coronal, axial, and sagittal planes), gross pathology, and line drawings for each gestation.
This simple and easy-to-use guide to fetal echocardiography will help physicians and sonographers obtain a complete evaluation of the normal and abnormal fetal heart. The book is written in a user-friendly style and thoroughly illustrated with ultrasound images accompanied by schematic drawings. This edition presents a comprehensive approach to the examination of the fetal heart and covers all major cardiac malformations. Chapters include color Doppler in fetal echocardiography, three-dimensional ultrasound in fetal echocardiography, first and early second trimester imaging of the fetal heart, and an updated genetics section. This book, written by internationally recognized experts in fetal echocardiography, is a must-have for physicians and sonographers interested in this field.
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions. Preterm birth is a cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, sociodemographic and neighborhood characteristics, environmental exposure, medical conditions, infertility treatments, and biological factors. Many of these factors co-occur, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority groups. While advances in perinatal and neonatal care have improved survival for preterm infants, those infants who do survive have a greater risk than infants born at term for developmental disabilities, health problems, and poor growth. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for public-sector services, such as health insurance, educational, and other social support systems. Preterm Birth assesses the problem with respect to both its causes and outcomes. This book addresses the need for research involving clinical, basic, behavioral, and social science disciplines. By defining and addressing the health and economic consequences of premature birth, this book will be of particular interest to health care professionals, public health officials, policy makers, professional associations and clinical, basic, behavioral, and social science researchers.
Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.