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"A subject collection from Cold Spring Harbor perspectives in biology."
“Mesozoic mammal fossils are the focus of this fascinating book, which reviews both the fossils themselves and the history of their discovery.” —Choice In Pursuit of Early Mammals presents the history of the mammals that lived during the Mesozoic era, the time when dinosaurs ruled the Earth, and describes their origins, anatomy, systematics, paleobiology, and distribution. It also tells the story of the author, a world-renowned specialist on these animals, and the other prominent paleontologists who have studied them. Zofia Kielan-Jaworowska was the first woman to lead large-scale paleontological expeditions, including eight to the Gobi Desert in Mongolia, which brought back important collections of dinosaur, early mammal, and other fossils. She shares the difficulties and pleasures encountered in finding rare fossils and describes the changing views on early mammals made possible by these discoveries. “A thorough review of the current state of early mammalian paleontology presented through the unique historical filter of someone who was at the foremost of the field for over half a century.” —The Quarterly Review of Biology “Whether she’s talking about how mammals evolved their distinctive ear bones, or how she built a cabin out of plywood during a particularly cold field season in the Gobi, you know that a remarkable, passionate person is telling a story of science and adventure in her own words.” —Priscum “A fascinating window into the development of the field . . . The perspective of an individual at the center of these developments is captivating, informative, and has never before been published.” —Gregory P. Wilson, University of Washington
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This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.
From a modest beginning in the form of a little shrew-like, nocturnal, insect eating ancestor that lived 200 million years ago, mammals evolved into the huge variety of different kinds of animals we see today. Many species are still small, and follow the lifestyle of the ancestor, but others have adapted to become large grazers and browsers, like the antelopes, cattle, rhinos, and elephants, or the lions, hyaenas, and wolves that prey upon them. Yet others evolved to be specialist termite eaters able to dig into the hardest mounds, or tunnel creating burrowers, and a few took to the skies as gliders and the bats. Many live partly in the water, such as otters, beavers, and hippos, while whales and dugongs remain permanently in the seas, incapable of ever emerging onto land. In this Very Short Introduction T. S. Kemp explains how it is a tenfold increase in metabolic rate - endothermy or "warm-bloodedness" - that lies behind the high levels of activity, and the relatively huge brain associated with complex, adaptable behaviour that epitomizes mammals. He describes the remarkable fossil record, revealing how and when the mammals gained their characteristics, and the tortuous course of their subsequent evolution, during which many bizarre forms such as sabre-toothed cats, and 30-tonne, 6-m high browsers arose and disappeared. Describing the wonderful adaptations that mammals evolved to suit their varied modes of life, he also looks at those of the mainly arboreal primates that culminated ultimately in Homo sapiens. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References