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Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies and is finding wider applications in areas such as biophysics and polymer science. In six chapters, Dynamic Force Spectroscopy and Biomolecular Recognition covers the most recent ideas and advances in the field of DFS applied to biorecognition: Chapter 1: Reviews the basic and novel aspects of biorecognition and discusses the emerging capabilities of single-molecule techniques to disclose kinetic properties and molecular mechanisms usually hidden in bulk measurements Chapter 2: Describes the basic principle of atomic force microsocopy (AFM) and DFS, with particular attention to instrumental and theoretical aspects more strictly related to the study of biomolecules Chapter 3: Overviews the theoretical background in which experimental data taken in nonequilibrum measurements of biomolecular unbinding forces are extrapolated to equilibrium conditions Chapter 4: Reviews the most common and efficient strategies adopted in DFS experiments to immobilize the interacting biomolecules to the AFM tip and to the substrate Chapter 5: Presents and discusses the most representative aspects related to the analysis of DFS data and the challenges of integrating well-defined criteria to calibrate data in automatic routinary procedures Chapter 6: Overviews the most relevant DFS applications to study biorecognition processes, including the biotin/avidin pair, and selected results on various biological complexes, including antigen/antibody, proteins/DNA, and complexes involved in adhesion processes Chapter 7: Summarizes the main results obtained by DFS applied to study biorecognition processes with forthcoming theoretical and experimental advances Although DFS is a widespread, worldwide technique, no books focused on this subject have been available until now. Dynamic Force Spectroscopy and Biomolecular Recognition provides the state of the art of experimental data analysis and theoretical procedures, making it a useful tool for researchers applying DFS to study biorecognition processes.
This book presents a series of integrated computer programs in Fortran-90 for the dynamic analysis of structures, using the finite element method. Two dimensional continuum structures such as walls are covered along with skeletal structures such as rigid jointed frames and plane grids. Response to general dynamic loading of single degree freedom systems is calculated, and the author also examines multi degree of freedom systems (including earthquake analysis). Each chapter covers a different aspect of analytic theory and the corresponding program segments. It will be an essential tool for practising structural and civil engineers, whilst also being of interest to academics and postgraduate students.
Effectively Apply the Systems Needed for Kinematic, Static, and Dynamic Analyses and DesignA survey of machine dynamics using MATLAB and SimMechanics, Kinematics and Dynamics of Mechanical Systems: Implementation in MATLAB and SimMechanics combines the fundamentals of mechanism kinematics, synthesis, statics and dynamics with real-world application
Beginning at an introductory level and progressing to more advanced topics, this handbook provides all the information needed to properly design, model, analyze, specify, and manufacture cam-follower systems. It is accompanied by a 90-day trial demonstration copy of the professional version of Dynacam.
This book provides a detailed and well-rounded overview of the dynamics of road vehicle systems. Readers will come to understand how physical laws, human factor considerations, and design choices come together to affect a vehicle's ride, handling, braking, and acceleration. Following an introduction and general review of dynamics, topics include: analysis of dynamic systems; tire dynamics; ride dynamics; vehicle rollover analysis; handling dynamics; braking; acceleration; and total vehicle dynamics.
Spectral Element Method in Structural Dynamics is a concise and timely introduction to the spectral element method (SEM) as a means of solving problems in structural dynamics, wave propagations, and other related fields. The book consists of three key sections. In the first part, background knowledge is set up for the readers by reviewing previous work in the area and by providing the fundamentals for the spectral analysis of signals. In the second part, the theory of spectral element method is provided, focusing on how to formulate spectral element models and how to conduct spectral element analysis to obtain the dynamic responses in both frequency- and time-domains. In the last part, the applications of SEM to various structural dynamics problems are introduced, including beams, plates, pipelines, axially moving structures, rotor systems, multi-layered structures, smart structures, composite laminated structures, periodic lattice structures, blood flow, structural boundaries, joints, structural damage, and impact forces identifications, as well as the SEM-FEM hybrid method. Presents all aspects of SEM in one volume, both theory and applications Helps students and professionals master associated theories, modeling processes, and analysis methods Demonstrates where and how to apply SEM in practice Introduces real-world examples across a variety of structures Shows how models can be used to evaluate the accuracy of other solution methods Cross-checks against solutions obtained by conventional FEM and other solution methods Comes with downloadable code examples for independent practice Spectral Element Method in Structural Dynamics can be used by graduate students of aeronautical, civil, naval architectures, mechanical, structural and biomechanical engineering. Researchers in universities, technical institutes, and industries will also find the book to be a helpful reference highlighting SEM applications to various engineering problems in areas of structural dynamics, wave propagations, and other related subjects. The book can also be used by students, professors, and researchers who want to learn more efficient and more accurate computational methods useful for their research topics from all areas of engineering, science and mathematics, including the areas of computational mechanics and numerical methods.
A comprehensive foundation in infrastructure design and analysis. Infrastructure Systems offers complete coverage of both static and dynamic analysis and design of infrastructure systems, from the basics of structural mechanics and dynamics to advanced analysis techniques. Bridging theory and applications, this invaluable book contains unique methods that simplify the analysis and design of nonlinear and complex linear infrastructural systems -powerful new tools for both informed students and practicing engineers. Well-written and easy to follow, Infrastructure Systems presents: * Fundamentals of statics, stress and deformation, and infrastructural dynamics of beams, frames, buildings, bridges, and other components * Equivalent systems, infrastructural nonlinearities, instability, and inelastic response for components of uniform or variable stiffness * A detailed examination of structures subjected to earthquake excitations and blast loadings -elastic and elastoplastic analyses, Lagrange's equation, and more * Energy concepts and applications, and the finite element and finite difference methods * Extensive examples and illustrations, plus detailed answers to selected problems.
Speech-act theory is the interdisciplinary study of the wide range of things we do with words. Originally stemming from the influential work of twentieth-century philosophers, including J. L. Austin and Paul Grice, recent years have seen a resurgence of work on the topic. On one hand, a new generation of linguists, philosophers, and cognitive scientists have made impressive progress toward reverse-engineering the psychological underpinnings that allow us to do so much with language. Meanwhile, speech-act theory has been used to enrich our understanding of pressing social issues that include freedom of speech, racial slurs, and the duplicity of political discourse. This volume presents fourteen new essays by many of the philosophers and linguists who have led this resurgence. The topics span a methodological range that includes formal semantics and pragmatics, foundational issues about the nature of linguistic representation, and work on a variety of forms of indirect and/or uncooperative speech that occupies the intersection of the philosophy of language, ethics, and political philosophy. Several of the contributions demonstrate the benefits of integrating the methodologies and perspectives of these literatures. The essays are framed by a comprehensive introductory survey of the contemporary literature written by the editors.