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From her apartment window, Doreen Durand witnesses a horrific accident. Officer Solloway wants to know what she saw. Doreen doesn't want to tell him - or anyone. But when she runs away it's straight into the fantastic world of the wealthy and mysterious Violet Cascade. With Officer Solloway in pursuit, and life becoming more bizarre by the day, Doreen is caught up in a surreal game of cat and mouse.
"When you're looking for an adventure, be careful. You might get just what you wish for..." Bramlingham Abbey sits alone and isolated, crumbling from neglect, hidden from sight by an ever-expanding jungle of vegetation. Violet Cobb, a fearless girl from the coastal town of Grimsby, is left on the doorstep - moved from her home during Operation Pied Piper, designed to keep the children of England safe during the bombing raids of World War Two. She is a conspicuous 'townie' in a quiet village of farmers, far away from her friends and family. Left alone with no one but an extremely elderly caretaker, Violet is left to explore the Abbey by herself. She soon discovers two things; that Bramblingham Abbey is full of secrets, and a strange girl called Sarah that no one else seems to know. Sarah claims to be the granddaughter of Lady Audrey, the mysterious owner of the Abbey - but how can this be? While exploring the Abbey, Violet makes a horrifying discovery about Sarah in the secret chapel. Furious with what Violet has discovered Lady Audrey lays down an ultimatum; that Violet, now aware of the secret, must leave the Abbey and the village forever. But all is not lost. You cannot hold onto the past forever - you have to move forwards and live...
Anagram Solver is the essential guide to cracking all types of quiz and crossword featuring anagrams. Containing over 200,000 words and phrases, Anagram Solver includes plural noun forms, palindromes, idioms, first names and all parts of speech. Anagrams are grouped by the number of letters they contain with the letters set out in alphabetical order so that once the letters of an anagram are arranged alphabetically, finding the solution is as easy as locating the word in a dictionary.
Short listed for The An Post Irish Novel of the Year 2021.00His name was Joseph, but for years they had called him Panenka, a name that was his sadness and his story.0Panenka has spent 25 years living with the disastrous mistakes of his past, which have made him an exile in his home town and cost him his dearest relationships.0Now aged 50, Panenka begins to rebuild an improvised family life with his estranged daughter and her seven year old son. But at night, Panenka suffers crippling headaches that he calls his Iron Mask. Faced with losing everything, he meets Esther, a woman who has come to live in the town to escape her own disappointments. Together, they find resonance in each other's experiences and learn new ways to let love into their broken lives.
A do-it-yourself manual for culturing nerve cells, complete with recipes and protocols.
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
The Form of Cities offers readers a considered theoretical introduction to the art of designing cities. Demonstrates that cities are replete with symbolic values, collective memory, association and conflict. Proposes a new theoretical understanding of urban design, based in political economy. Demonstrates different ways of conceptualising the city, whether through aesthetics or the prism of gender, for example. Written in an engaging and jargon-free style, but retains a sophisticated interpretative edge. Complements Designing Cities by the same author (Blackwell, 2003).
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Landscape Architecture Regenerative Design for Sustainable Development Winner, 1994 MeritAward for Communications, American Society of LandscapeArchitects "Regenerative Design for Sustainable Development is nothing lessthan a user's manual for planet Earth that integrates theprinciples of ecological design with practical realities betterthan anything I've read. John Lyle has written the best book nowavailable on the theory and practice of sustainability . . .essential reading for natural resource professionals, architects,planners, educators, environmentalists, and the general public."--David W. Orr, Professor and Chair Environmental Studies Program,Oberlin College. "John Lyle has written a splendid book, Regenerative Design forSustainable Development. It is perfectly topical; it is committedto the unity of art and science, design and planning, man andnature. It is itself exemplary, and it is a repository of exemplaryadaptations. It has carried the environmental movement to a newthreshold of ecological planning and design. It should be widelyread and employed." --Ian L. McHarg, FASLA. "In these times of widespread urban stress and regional disruption,the cogent thoughts of John Tillman Lyle on sustainable cities areon target and highly constructive. They are must reading forplanning professionals and all concerned citizens." --John OrmsbeeSimonds, FASLA. "More designers need to broaden their horizons in the way John Lylehas put forth in this book. In general, there are far too few landplanners, landscape architects, or architects who have any workingprocedure that approximates what sustainable design entails. Thisbook provides important historical background and contemporaryexperience to help guide the way."--Pliny Fisk III, Center forMaximum Potential Building Systems. From the despoliation of our rivers and lakes by industrial runoffto the destruction of our atmosphere by sulphur emissions and CFCs,production cycles based on a one-way flow of materials and energyhave pushed us to the brink of environmental collapse. It is timefor a change, and in this groundbreaking book, John Tillman Lyleoffers us a blueprint for implementing that change. This book provides civil engineers, architects, land developmentplanners, and others with practical, realistic approaches toreversing this deadly course. Throughout, the emphasis is on provenregenerative practices for water use, land use, energy use, andbuilding design. Most importantly, it provides ways to reestablishconnections between people and nature, between art and science, andbetween technology and daily life.
Fully revised and updated, Processing Contaminants in Edible Oils, 2nd edition, presents the latest research on monochloropropanediol (MCPD) and glycidyl esters in edible oils. These potentially harmful contaminants are formed during the industrial processing of food oils during deodorization. A number of advancements in understanding these have been made since the publication of the first edition. These important changes, which impact industrial mitigation, analytical methods, toxicology and regulation, are highlighted for up-to-date reference. The mechanisms of formation for MCPD and glycidyl ester contaminants, as well as research identifying possible precursor molecules are reviewed, as are strategies which have been used successfully to decrease the concentrations of these contaminants. From the removal of precursor molecules before processing, modifications of deodorization protocol, to approaches for the removal of these contaminants after the completion of processing, methods of mitigating and eliminating contaminants are presented. - Include a new chapter on methods for MCPD and glycidyl esters in food - Details the mechanisms of formation for these contaminants and research identifying possible precursor molecules - Presents successful strategies to decrease the concentrations of these contaminants in edible oils - Includes analytical strategies for accurate detection and quantitation of the contaminants along with their toxicological properties