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“A riveting scientific detective story” (The Washington Post) by two Pulitzer Prize–winning journalists who chronicle a young Wisconsin boy with a never-before-seen disease and the doctors who save his life by taking a new step into the future of medicine. In this landmark medical narrative, Pulitzer Prize-winning journalists Mark Johnson and Kathleen Gallagher share the story of Nic Volker, the first patient to be saved by a bold breakthrough in medicine—a complete gene sequencing, aimed at finding the cause of an otherwise undiagnosable illness. At just two years old, Nic experienced a brief flicker of pain that signaled the awakening of a new and deadly disease, one that would hurl him and his family into a harrowing journey in search for a lifesaving cure. After his symptoms stump every practitioner, it becomes clear that Nic’s is a one in a billion case, a disease that no one has ever seen before. As Nic and his family search for answers, the scientific community is racing to bring about the next revolution in medicine—translating results from the Human Genome Project to treatments for actual patients. At the forefront is the brilliant geneticist Howard Jacob, who starts a lab at the Medical College of Wisconsin. Then Nic’s head physician reaches out to Jacob with an unprecedented of idea. A disease like Nic’s is likely due to a rare mutation: if they could sequence his genes to try to find the mutation, the boy might live. Jacob doesn’t know if he can do it; Nic’s doctors don’t know if it will even work; and no one knows what else might lie in the Pandora’s Box of Nic’s genome. But they decide to try—and in doing so, they step into a new era of medicine. One in a Billion is “a compelling story of a modern medical miracle—the first instance of personalized medicine” (Milwaukee Journal Sentinel) and the birth of a scientific revolution.
"There are books—few and far between—which carefully, delightfully, and genuinely turn your head inside out. This is one of them. It ranges over some central issues in Western philosophy and begins the long overdue job of giving us a radically new account of meaning, rationality, and objectivity."—Yaakov Garb, San Francisco Chronicle
Mark Johnson's father had 'LOVE' tattooed across his left hand, but that didn't stop the beatings. The Johnson children would turn up to school with broken fingers and chipped teeth, but no one ever thought of investigating their home life. Mark just slipped through the cracks, and kept on falling. For years. Constantly in trouble at school, Mark began stealing at the age of seven, was drinking by the age of eight, and took his first hit of heroin aged eleven. A sensitive, intelligent boy, he could never stay on the right path, and though Art College beckoned, he ended up in Portland prison instead. With searing honesty, WASTED documents Mark's descent into the depths of addiction and criminality. Homeless, hooked on heroin and crack, no one - least of all Mark - believed he would survive. And yet - astonishingly - he somehow pulled himself through, and now runs his own thriving tree surgery business, employing and helping other recovering addicts. His story is at once shocking and inspiring - a compelling account of his struggle to save himself, and help save others in the process.
This sereis of short stories won an award in 2012. When photographer Mark Johnson tires of the world of being a celebrity photographer, he retires to the coast with only his close friend, and agent as his contact with society. His retirement is interupted when he decides to investigate his sighting of a mysterious ghostly figure in the window of a derelict house by the cliffs. This leads him into a series of encounters with ghosts, and demons, while fighting his demons.
A "smoothly written and fair-minded" (Wall Street Journal) biography of architect Philip Johnson -- a finalist for the National Book Critic's Circle Award. When Philip Johnson died in 2005 at the age of 98, he was still one of the most recognizable and influential figures on the American cultural landscape. The first recipient of the Pritzker Prize and MoMA's founding architectural curator, Johnson made his mark as one of America's leading architects with his famous Glass House in New Caanan, CT, and his controversial AT&T Building in NYC, among many others in nearly every city in the country -- but his most natural role was as a consummate power broker and shaper of public opinion. Johnson introduced European modernism -- the sleek, glass-and-steel architecture that now dominates our cities -- to America, and mentored generations of architects, designers, and artists to follow. He defined the era of "starchitecture" with its flamboyant buildings and celebrity designers who esteemed aesthetics and style above all other concerns. But Johnson was also a man of deep paradoxes: he was a Nazi sympathizer, a designer of synagogues, an enfant terrible into his old age, a populist, and a snob. His clients ranged from the Rockefellers to televangelists to Donald Trump. Award-winning architectural critic and biographer Mark Lamster's The Man in the Glass House lifts the veil on Johnson's controversial and endlessly contradictory life to tell the story of a charming yet deeply flawed man. A rollercoaster tale of the perils of wealth, privilege, and ambition, this book probes the dynamics of American culture that made him so powerful, and tells the story of the built environment in modern America.
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.
A memoir by the internationally famous fashion designer and style icon Mention the name "Betsey Johnson" and almost every woman from the age of 15 to 75 can rapturously recall a favorite dress or outfit; whether worn for a prom, a wedding, or just to stand out from the crowd in a colorful way. They may also know her as a renegade single mom who palled around with Edie Sedgwick, Twiggy, and The Velvet Underground, or even as a celebrity contestant on Dancing with the Stars. Betsey is also famous for her iconic pink stores (she had 65 shops across the US) and for her habit of doing cartwheels and splits down the runway at the close of her fashion shows. Throughout her decades-long career, she's taken pride in producing fun but rule-breaking clothing at an accessible price point. What they might not know is that she built an empire from scratch, and brought stretch clothing to the masses in the 80s and 90s. Betsey will take the reader behind the tutu and delve deeply into what it took to go from a white picket fence childhood in Connecticut to becoming an internationally known force in a tough, competitive business. The book will feature Betsey's candid memories of the fashion and downtown scene in the 60s and how she started her own business from the ground up after designing successfully for multiple other companies. She will discuss that business's ups and downs and reinventions (including bankruptcy), and her thoughts on body image, love, divorce, men, motherhood, and her bout with breast cancer. Betsey will be richly illustrated with many of her landmark clothes, fashion sketches, and personal photos--making the book the perfect memento and gift for every girl (of any age) for whom Betsey is, as a recent New York Times profile noted, "a role model still."
A twenty-fifth anniversary edition of Charles Johnson’s National Book Award-winning masterpiece—"a novel in the tradition of Billy Budd and Moby-Dick…heroic in proportion…fiction that hooks the mind" (The New York Times Book Review)—now with a new introduction from Stanley Crouch. Rutherford Calhoun, a newly freed slave and irrepressible rogue, is lost in the underworld of 1830s New Orleans. Desperate to escape the city’s unscrupulous bill collectors and the pawing hands of a schoolteacher hellbent on marrying him, he jumps aboard the Republic, a slave ship en route to collect members of a legendary African tribe, the Allmuseri. Thus begins a voyage of metaphysical horror and human atrocity, a journey which challenges our notions of freedom, fate and how we live together. Peopled with vivid and unforgettable characters, nimble in its interplay of comedy and serious ideas, this dazzling modern classic is a perfect blend of the picaresque tale, historical romance, sea yarn, slave narrative and philosophical allegory. Now with a new introduction from renowned writer and critic Stanley Crouch, this twenty-fifth anniversary edition of Middle Passage celebrates a cornerstone of the American canon and the masterwork of one of its most important writers. "Long after we’d stopped believe in the great American novel, along comes a spellbinding adventure story that may be just that" (Chicago Tribune).
While political history has plenty to say about the impact of Ronald Reagan’s election to the presidency in 1980, four Senate races that same year have garnered far less attention—despite their similarly profound political effect. Tuesday Night Massacre looks at those races. In examining the defeat in 1980 of Idaho’s Frank Church, South Dakota’s George McGovern, John Culver of Iowa, and Birch Bayh of Indiana, Marc C. Johnson tells the story of the beginnings of the divisive partisanship that has become a constant feature of American politics. The turnover of these seats not only allowed Republicans to gain control of the Senate for the first time since 1954 but also fundamentally altered the conduct of American politics. The incumbents were politicians of national reputation who often worked with members of the other party to accomplish significant legislative objectives—but they were, Johnson suggests, unprepared and ill-equipped to counter nakedly negative emotional appeals to the “politically passive voter.” Such was the campaign of the National Conservative Political Action Committee (NCPAC), the organization founded by several young conservative political activists who targeted these four senators for defeat. Johnson describes how such groups, amassing a great amount of money, could make outrageous and devastating claims about incumbents—“baby killers” who were “soft on communism,” for example—on behalf of a candidate who remained above the fray. Among the key players in this sordid drama are NCPAC chairman Terry Dolan; Washington lobbyist Charles Black, a top GOP advisor to several presidential campaigns and one-time business partner of Paul Manafort; and Roger Stone, self-described “dirty trickster” for Richard Nixon and confidant of Donald Trump. Connecting the dots between the Goldwater era of the 1960s and the ascent of Trump, Tuesday Night Massacre charts the radicalization of the Republican Party and the rise of the independent expenditure campaign, with its divisive, negative techniques, a change that has deeply—and perhaps permanently—warped the culture of bipartisanship that once prevailed in American politics.
For fans of Wrinkle in Time and The School of Good and Evil, the New York Times bestseller The Mark of the Dragonfly is a fast-paced adventure story about a mysterious girl and a fearless boy, set in a magical world that is both exciting and dangerous. Piper has never seen the Mark of the Dragonfly until she finds the girl amid the wreckage of a caravan in the Meteor Fields. The girl doesn’t remember a thing about her life, but the intricate tattoo on her arm is proof that she’s from the Dragonfly Territories and that she’s protected by the king. Which means a reward for Piper if she can get the girl home. The one sure way to the Territories is the 401, a great old beauty of a train. But a ticket costs more coin than Piper could make in a year. And stowing away is a difficult prospect—everyone knows that getting past the peculiar green-eyed boy who stands guard is nearly impossible. Life for Piper just turned dangerous. A little bit magical. And very exciting, if she can manage to survive the journey. Praise for The Mark of the Dragonfly: ★ “This magnetic middle-grade debut…[is] a page-turner that defies easy categorization and ought to have broad appeal.”—Publishers Weekly, Starred ★ “Heart, brains, and courage find a home in a steampunk fantasy worthy of a nod from Baum.”-- Kirkus Reviews, Starred ★ “A fantastic and original tale of adventure and magic...Piper is a heroine to fall in love with: smart, brave, kind, and mechanically inclined to boot.”—School Library Journal, Starred “A complex and impeccably developed plot—there is plenty to recommend in this novel.”—The Bulletin “Appealing characters and lots of action make it a good choice for young adventure readers.”—Booklist