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In the mid-1870s, the experimental therapy of lamb blood transfusion spread like an epidemic across Europe and the USA. Doctors tried it as a cure for tuberculosis, pellagra and anemia; proposed it as a means to reanimate seemingly dead soldiers on the battlefield. It was a contested therapy because it meant crossing boundaries and challenging taboos. Was the transfusion of lamb blood into desperately sick humans really defensible? The book takes the reader on a journey into hospital wards and lunatic asylums, physiological laboratories and 19th century wars. It presents a fascinating story of medical knowledge, ambitions and concerns - a story that provides lessons for current debates on the morality of medical experimentation and care.
Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume. Praise for the First Edition: "... very useful as an introduction to clinical research, or for those planning specific studies within therapeutic or disease areas." BRITISH JOURNAL OF SURGERY, Vol. 92, No. 2, February 2005 The book’s main concept is to describe the impact of clinical trials on the practice of medicine. It separates the information by therapeutic area because the impact of clinical trials, the problems encountered, and the numbers of trials in existence vary tremendously from specialty to specialty. The sections provide a background to the disease area and general clinical trial methodology before concentrating on particular problems experienced in that area. Specific examples are used throughout to address these issues. The Textbook of Clinical Trials, Second Edition: Highlights the various ways clinical trials have influenced the practice of medicine in many therapeutic areas Describes the challenges posed by those conducting clinical trials over a range of medical specialities and allied fields Additional therapeutic areas are included in this Second Edition to fill gaps in the First Edition as the number and complexity of trials increases in this rapidly developing area Newly covered or updated in the Second Edition: general surgery, plastic surgery, aesthetic surgery, palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal, thyroid and urological cancers, as well as a chapter on the Cochrane network An invaluable resource for pharmaceutical companies, the Textbook of Clinical Trials, Second Edition appeals to those working in contract research organizations, medical departments and in the area of public health and health science alike.
With over 350 illustrations, this impressive volume traces the rich history of ideas about the functioning of the brain from its roots in the ancient cultures of Egypt, Greece, and Rome through the centuries into relatively modern times. In contrast to biographically oriented accounts, this book is unique in its emphasis on the functions of the brain and how they came to be associated with specific brain regions and systems. Among the topics explored are vision, hearing, pain, motor control, sleep, memory, speech, and various other facets of intellect. The emphasis throughout is on presenting material in a very readable way, while describing with scholarly acumen the historical evolution of the field in all its amazing wealth and detail. From the opening introductory chapters to the concluding look at treatments and therapies, this monumental work will captivate readers from cover to cover. It will be valued as both an historical reference and as an exciting tale of scientificdiscovery. It is bound to attract a wide readership among students and professionals in the neural sciences as well as general readers interested in the history of science and medicine.
Recent scandals and controversies, such as data fabrication in federally funded science, data manipulation and distortion in private industry, and human embryonic stem cell research, illustrate the importance of ethics in science. Responsible Conduct of Research, now in a completely updated second edition, provides an introduction to the social, ethical, and legal issues facing scientists today.
This report provides information about aluminum and the human health effects of exposure. This chemical has been found in many sites identified by the EPA for long-term Federal cleanup activities. The report includes a Public Health Statement which explains the toxicologic properties of aluminum in a nontechnical, Q&A format, and a review of the general health effects observed following exposure; a description of health effects; how the chemical can affect children; and information on its chemical and physical properties, production, use and disposal, potential for human exposure, analytical methods, and regulations and advisories.
This book examines how and why British imperial rule shaped scientific knowledge about malaria and its cures in nineteenth-century India. This title is also available as Open Access.
This book shows how vitamin A deficiency – before the vitamin was known to scientists – affected millions of people throughout history. It is a story of sailors and soldiers, penniless mothers, orphaned infants, and young children left susceptible to blindness and fatal infections. We also glimpse the fortunate ones who, with ample vitamin A-rich food, escaped this elusive stalker. Why were people going blind and dying? To unravel this puzzle, scientists around the world competed over the course of a century. Their persistent efforts led to the identification of vitamin A and its essential role in health. As a primary focus of today’s international public health efforts, vitamin A has saved hundreds of thousands of lives. But, we discover, they could save many more were it not for obstacles erected by political and ideological zealots who lack a historical perspective of the problem. Although exhaustively researched and documented, this book is written for intellectually curious lay readers as well as for specialists. Public health professionals, nutritionists, and historians of science and medicine have much to learn from this book about the cultural and scientific origins of their disciplines. Likewise, readers interested in military and cultural history will learn about the interaction of health, society, science, and politics. The author’s presentation of vitamin A deficiency is likely to become a classic case study of health disparities in the past as well as the present.
For seasoned professionals as well as students, A History of Public Health is visionary and essential reading.
How should we treat non-human animals? In this immensely powerful and influential book (now with a new introduction by Sapiens author Yuval Noah Harari), the renowned moral philosopher Peter Singer addresses this simple question with trenchant, dispassionate reasoning. Accompanied by the disturbing evidence of factory farms and laboratories, his answers triggered the birth of the animal rights movement. 'An extraordinary book which has had extraordinary effects... Widely known as the bible of the animal liberation movement' Independent on Sunday In the decades since this landmark classic first appeared, some public attitudes to animals may have changed but our continued abuse of animals in factory farms and as tools for research shows that the underlying ideas Singer exposes as ethically indefensible are still dominating the way we treat animals. As Yuval Harari’s brilliantly argued introduction makes clear, this book is as relevant now as the day it was written.