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The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases. The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics
The flagship title of the certification suite from the American College of Sports Medicine, ACSM's Guidelines for Exercise Testing and Prescription is a handbook that delivers scientifically based standards on exercise testing and prescription to the certification candidate, the professional, and the student. The 9th edition focuses on evidence-based recommendations that reflect the latest research and clinical information. This manual is an essential resource for any health/fitness and clinical exercise professional, physician, nurse, physician assistant, physical and occupational therapist, dietician, and health care administrator. This manual give succinct summaries of recommended procedures for exercise testing and exercise prescription in healthy and diseased patients.
Biohydrogen Production: Fundamentals and Technology Advances covers the fundamentals of biohydrogen production technology, including microbiology, biochemistry, feedstock requirements, and molecular biology of the biological hydrogen production processes. It also gives insight into scale-up problems and limitations. In addition, the book discusses mathematical modeling of the various processes involved in biohydrogen production and the software required to model the processes. The book summarizes research advances that have been made in this field and discusses bottlenecks of the various processes, which presently limit the commercialization of this technology. The authors also focus on the process economy, policy, and environmental impact of this technology, since the future of biohydrogen production depends not only on research advances, but also on economic considerations (the cost of fossil fuels), social espousal, and the development of H2 energy systems. The book describes the fundamentals of this technology interwoven with more advanced research findings. Further reading is suggested at the end of each chapter. Since the beauty of any innovation is its applicability, socioeconomic impact, and cost energy analysis, the book examines each of these points to give you a holistic picture of this technology. Illustrative diagrams, flow charts, and comprehensive tables detailing the scientific advancements provide an opportunity to understand the process comprehensively and meticulously. Written in a lucid style, the book supplies a complete knowledge bank about biohydrogen production processes.
The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function, Second Edition, offers a fresh approach to the teaching of molecular biology by focusing on the commonalities that exist between the three kingdoms of life, and discussing the differences between the three kingdoms to offer instructive insights into molecular processes and components. This gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity. Additionally, an integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics As an experimental science, molecular biology requires an appreciation for the approaches taken to yield the information from which concepts and principles are deduced. Experimental Approach panels throughout the text describe research that has been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Molecular Biology further enriches the learning experience with full-color artwork, end-of-chapter questions and summaries, suggested further readings grouped by topic, and an extensive glossary of key terms. Features: A focus on the underlying principles of molecular biology equips students with a robust conceptual framework on which to build their knowledge An emphasis on their commonalities reflects the processes and components that exist between bacteria, archae, and eukaryotes Experimental Approach panels demonstrate the importance of experimental evidence by describing research that has been particularly valuable in the field
This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
The author was motivated to write this important book because currently there is no systematically-written document on the ZIKV disease, which could serve at this crucial moment as a textbook for medical students, physicians, nurses, and other healthcare providers as well as a reference book for basic researchers, professors, and the general public. The original concept of ZIKV-Charnolopathy due to compromised mitochondrial bioenergetics in highly vulnerable (neural progenitor cells, spermatocytes, oocytes etc.) cells and its amelioration by physiological and/or pharmacological interventions is based on years of research experience. This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilizers as promising charnolopharmacotherapeutics. They are meant to aid in the prevention and treatment of the ZIKV-linked diversified spectrum of neurodevelopmental anomalies (embryopathies) in newborn infants and Guillain Barre' Syndrome (GBS) in adults. Clinical management of ZIKV-induced GBS employing IV immunoglobulin and plasmapheresis (plasma exchange) is also described.
Bonduriansky and Day challenge the premise that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. They explore the latest research showing that what happens during our lifetimes--and even our parents' and grandparents' lifetimes--can influence the features of our descendants. Based on this evidence, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations, opening the door to a new understanding of inheritance, evolution, and even human health. --Adapted from publisher description.
Molecular Biology is the story of the molecules of life, their relationships, and how these interactions are controlled. It is an expanding field in life sciences, and its applications are wide and growing. We can now harness the power of molecular biology to treat diseases, solve crimes, map human history, and produce genetically modified organisms and crops, and these applications have sparked a multitude of fascinating legal and ethical debates. In this Very Short Introduction, Aysha Divan and Janice Royds examine the history, present, and future of Molecular Biology. Starting with the building blocks established by Darwin, Wallace and Mendel, and the discovery of the structure of DNA in 1953, they consider the wide range of applications for Molecular Biology today, including the development of new drugs, and forensic science. They also look forward to two key areas of evolving research such as personalised medicine and synthetic biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their individual field of study offering readers current data and information on the rapidly changing subjects in molecular biology.