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Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.
This biographical study illuminates the important yet misunderstood figure of Barbara McClintock, the Nobel Prize winning geneticist. Comfort replaces the myth with a new story, rich with new understandings of women in science.
This challenging and innovative book examines the processes involved in the birth and development of new scientific ideas. The author has searched for strategies used by scientists for producing new theories, both those that yield a range of plausible hypotheses and ones that aid in narrowing that range. She goes on to focus on the development of the theory of the gene as a case study in scientific creativity. Her discussion of modern genetics greatly demystifies the philosophy of science, and establishes a realistic framework for understanding how scientists actually go about their work. This compelling work will interest a broad range of readers, including biologists and geneticists, along with historians and philosophers of science.
Philosophers of science frequently bemoan (or cheer) the fact that today, with the supposed collapse of logical empiricism, there are now ;;10 grand systems. However, although this mayor may not be true, and if true mayor may not be a cause for delight, no one should conclude that the philosophy of science has ground to a halt, its problems exhausted and its practioners dispirited. In fact, in this post Kuhnian age the subject has never been more alive, as we work with enthusiasm on special topics, historical and conceptual. And no topic has grown and thrived quite like the philosophy of biology, which now has many students in the field producing high-quality articles and monographs. The success of this subject is due above all to the work and influence of one man: David Hull. In his own writings and in the support he has given to others, he has shown true leadership, in the best Platonic sense. It is now twenty years since Hull fnt gave his seminal paper 'What the philosophy of biology is not', and to mark that point and to show our respect, gratitude and affection to its author, a number of us who owe much to Hull decided to produce a volume of essays on and around themes to which Hull has spoken.
The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.
Essential themes in the development of the life sciences during the nineteenth century.
Bonduriansky and Day challenge the premise that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. They explore the latest research showing that what happens during our lifetimes--and even our parents' and grandparents' lifetimes--can influence the features of our descendants. Based on this evidence, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations, opening the door to a new understanding of inheritance, evolution, and even human health. --Adapted from publisher description.