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Catalog of an exhibition held May 1, 2010-Aug. 14, 2010 at Haunch of Venison in London.
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
David Livingstone (1813-73) was a Scottish missionary and medical doctor who explored much of the interior of Africa. In a remarkable journey in 1853-56, he became the first European to cross the African continent. Starting on the Zambezi River, he traveled north and west across Angola to reach the Atlantic at Luanda. On his return journey he followed the Zambezi to its mouth on the Indian Ocean in present-day Mozambique. Livingstone's most famous expedition was in 1866-73, when he explored central Africa in an attempt to find the source of the Nile. Not heard from for years, he was believed lost. Both the Royal Geographical Society and the sensationalist New York Herald organized expeditions to find him. Henry M. Stanley (1841-1904), a British-born reporter who was to become a noted explorer in his own right, led the Herald's expedition. On November 10, 1871, Stanley found Livingstone in the town of Ujiji, on the shores of Lake Tanganyika, in present-day Tanzania. News of the discovery caused a worldwide sensation. This book, which appeared in Chicago in 1872, was part of the effort by publishers to capitalize on the demand from the public for information about Livingstone and Stanley and about Africa in general.