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Hailed by John le Carré as “an act of courage on the part of its author” and singled out for praise by the leading medical journals in the United States and the United Kingdom, The Body Hunters uncovers the real-life story behind le Carré's acclaimed novel The Constant Gardener and the feature film based on it. "A trenchant exposé . . . meticulously researched and packed with documentary evidence" (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, “it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories,” which tell of an impossible choice being faced by many of the world's poorest patients—be experimented upon or die for lack of medicine.
The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
Return to the world of the FBI’s Krewe of Hunters as they try to stop a resurrected evil from taking more lives, in book 3 of this thrilling series from New York Times bestselling author Heather Graham. The details of the crime scene are no coincidence. The body—a promising starlet—has been battered, bloodied and then discarded between two of Manhattan’s oldest graveyards. One look and Detective Jude Crosby recognizes the tableau: a re-creation of Jack the Ripper’s gruesome work. But he also sees something beyond the actions of a mere copycat. Something more dangerous…and unexplainable. As the city seethes with suspicion, Jude calls on Whitney Tremont, a member of the country’s preeminent paranormal investigating team, to put the speculation to rest. Yet when Whitney and Jude delve deeper, what they discover is more shocking than either could have predicted, and twice as sinister… Previously published in 2011
Paranormal investigator Katya Sokolov is called in to save a documentary film after divers are inexplicably dying while working on the film.
A chilling account of the murders of two hunters in rural Michigan—a mystery that haunted a community and baffled the police for two decades. In the bitter cold of 1985, two buddies from Detroit embark on a hunting trip to the Michigan wilderness, unaware they will soon become the hunted. The eerie silence surrounding their sudden disappearance is broken after nearly two decades when a relentless investigator inspires a terrified witness to break her silence. The witness narrates a haunting scene that had unfolded years back, pointing fingers at the prime suspects—the Duvall brothers. With no bodies unearthed, the justice system is riveted by the startling revelations during an electrifying trial in 2003. The brothers, Raymond and Donald Duvall, had bragged about the murders, evocatively explaining how they dismembered their victims and fed them to pigs. Despite the shocking confession, the case holds its ground purely on a single witness’s account, taking the courtroom through a labyrinth of dark secrets and sinister acts. This gripping thriller presents a vivid tale of crime that reveals the devastating power of evil.
Basing his study on firsthand experience with Yukaghir hunters, Rane Willerslev focuses on the practical implications of living in a 'hall of mirrors' world, one inhabited by humans, animals and spirits, all of whom are understood to be endless mimetic doubles of one another.
The Experiment Must Continue is a beautifully articulated ethnographic history of medical experimentation in East Africa from 1940 through 2014. In it, Melissa Graboyes combines her training in public health and in history to treat her subject with the dual sensitivities of a medical ethicist and a fine historian. She breathes life into the fascinating histories of research on human subjects, elucidating the hopes of the interventionists and the experiences of the putative beneficiaries. Historical case studies highlight failed attempts to eliminate tropical diseases, while modern examples delve into ongoing malaria and HIV/AIDS research. Collectively, these show how East Africans have perceived research differently than researchers do and that the active participation of subjects led to the creation of a hybrid ethical form. By writing an ethnography of the past and a history of the present, Graboyes casts medical experimentation in a new light, and makes the resounding case that we must readjust our dominant ideas of consent, participation, and exploitation. With global implications, this lively book is as relevant for scholars as it is for anyone invested in the place of medicine in society.
Facing the risks of nineteenth-century sailing, including pirates and unscrupulous captains, a young mate sets his sights on a whale with an unusual reputation and finds his crew stalked by a menacing force.
During her two decades at The New England Journal of Medicine, Dr. Marcia Angell had a front-row seat on the appalling spectacle of the pharmaceutical industry. She watched drug companies stray from their original mission of discovering and manufacturing useful drugs and instead become vast marketing machines with unprecedented control over their own fortunes. She saw them gain nearly limitless influence over medical research, education, and how doctors do their jobs. She sympathized as the American public, particularly the elderly, struggled and increasingly failed to meet spiraling prescription drug prices. Now, in this bold, hard-hitting new book, Dr. Angell exposes the shocking truth of what the pharmaceutical industry has become–and argues for essential, long-overdue change. Currently Americans spend a staggering $200 billion each year on prescription drugs. As Dr. Angell powerfully demonstrates, claims that high drug prices are necessary to fund research and development are unfounded: The truth is that drug companies funnel the bulk of their resources into the marketing of products of dubious benefit. Meanwhile, as profits soar, the companies brazenly use their wealth and power to push their agenda through Congress, the FDA, and academic medical centers. Zeroing in on hugely successful drugs like AZT (the first drug to treat HIV/AIDS), Taxol (the best-selling cancer drug in history), and the blockbuster allergy drug Claritin, Dr. Angell demonstrates exactly how new products are brought to market. Drug companies, she shows, routinely rely on publicly funded institutions for their basic research; they rig clinical trials to make their products look better than they are; and they use their legions of lawyers to stretch out government-granted exclusive marketing rights for years. They also flood the market with copycat drugs that cost a lot more than the drugs they mimic but are no more effective. The American pharmaceutical industry needs to be saved, mainly from itself, and Dr. Angell proposes a program of vital reforms, which includes restoring impartiality to clinical research and severing the ties between drug companies and medical education. Written with fierce passion and substantiated with in-depth research, The Truth About the Drug Companies is a searing indictment of an industry that has spun out of control.
William Blake and the Body re-evaluates Blake's central image: the human form. In Blake's designs, transparent-skinned bodies passionately contort; in his verse, metamorphic bodies burst from each other in gory, gender-bending births. The culmination is an ideal body uniting form and freedom. Connolly explores romantic-era contexts like anatomical art, embryology, miscarriage and twentieth-century theorists like those of Kristeva, Douglas, Girard to provide an innovative new analysis of Blake's transformations of body and identity.