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To study magic at the University, Siobhan sacrificed her name. She sacrificed her body, and her past. Magically disguised as a boy named Sebastien, she is learning wondrous secrets of the thaumaturgic sciences. As Sebastien, she mingles with the young nobles who will one day rule their country. But danger is closer than ever, and she cannot escape her past. The coppers investigating the theft of Siobhan's priceless transformation artifact have given her a new name. The Raven Queen. As Siobhan does favors for the gang that loaned her the University tuition, the Raven Queen's mystique only grows. And keeps growing... ...Snowballing out of control until Siobhan's other identity takes on a life of its own, a fear-inducing bogeyman well beyond the truth of her real capabilities. With the whole city out to get her and trouble hounding both sides of her double life, how will Siobhan ever survive to become the world's most powerful sorcerer?
The second novel in the international No. 1 bestselling Mercy Thompson series - the major urban fantasy hit of the decade. 'I love these books!' Charlaine Harris 'The best new fantasy series I've read in years' Kelley Armstrong MERCY THOMPSON: MECHANIC, SHAPESHIFTER, FIGHTER Like most people who own their own business, I work long hours that start early in the morning. So when someone calls me in the middle of the night, they'd better be dying ... Mechanic Mercy Thompson is woken at 3am by a vampire calling in a favour. He has to deliver a message to a fellow undead and needs a witness that won't be noticed - and Mercy's shapeshifting abilities make her the perfect candidate. But the assignment turns into a bloodbath and Mercy attracts the attention of not just a powerful vampire, but the even more powerful demon possessing him. She can count on the supernatural community for protection - and alpha werewolf Adam would like her to rely on him in other ways too - but when it comes to being proactive, she's on her own. Praise for the series: 'Plenty of twists and turns . . . Kept me entertained from its deceptively innocent beginning to its can't-put-it-down end' Kim Harrison, bestselling author of Dead Witch Walking 'I enjoyed every minute of it. I love Mercy and can't wait for her to kick some more ass' Lilith Saintcrow The Mercy Thompson books: Moon Called Blood Bound Iron Kissed Bone Crossed Silver Borne River Marked Frost Burned Night Broken Fire Touched Silence Fallen Storm Cursed Shifting Shadows (Stories from the world of Mercy Thompson)
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Of Blood and Fire is a classic Epic Fantasy adventure. It takes all the familiar fantasy tropes - elves, dwarves, giants, and dragons - and adds a fresh, contemporary twist.
The heir of ash and fire bows to no one. A new threat rises in the third book in the #1 bestselling Throne of Glass series by Sarah J. Maas. Celaena Sardothien has survived deadly contests and shattering heartbreak, but now she must travel to a new land to confront her darkest truth. That truth could change her life-and her future-forever. Meanwhile, monstrous forces are gathering on the horizon, intent on enslaving her world. To defeat them, Celaena will need the strength not only to fight the evil that is about to be unleashed but also to harness her inner demons. If she is to win this battle, she must find the courage to face her destiny-and burn brighter than ever before. The third book in the #1 New York Times bestselling Throne of Glass series continues Celaena's epic journey from woman to warrior.
In a world where magic is a science, Siobhan is a genius. But even geniuses need schooling. Siobhan has just been banned from the country's only magical university. As the unwitting accomplice to the theft of a priceless magical artifact, she has suddenly become a wanted criminal. There are fates worse than death, and if caught, she will face them. Unwilling to give up on her dream of becoming the world's most powerful sorcerer, she resolves to do whatever it takes to change her fate. Even if it means magically disguising herself as a man and indebting herself to a gang of criminals to pay for University tuition. With the coppers after her, the pressure of trying to keep her spot in the devilishly competitive magic classes, and the gang calling in favors to repay her debts, Siobhan will need every drop of magic she can channel. Search terms: magepunk, progression fantasy, hard fantasy, unique magic system, realistic magic system, magic university, academy fantasy, magic lessons, gender bender, gender switch, gaslamp, spellcasting, sorcerers, witches, scp, alternate universe fantasy, alternate world fantasy, historical fantasy, magical creatures
The emergence of symbolic culture is generally linked with the development of the hunger-gatherer adaptation based on a sexual division of labor. This original and ingenious book presents a new theory of how this symbolic domain originated. Integrating perspectives of evolutionary biography and social anthropology within a Marxist framework, Chris Knight rejects the common assumption that human culture was a modified extension of primate behavior and argues instead that it was the product of an immense social, sexual, and political revolution initiated by women. Culture became established, says Knight, when evolving human females began to assert collective control over their own sexuality, refusing sex to all males except those who came to them with provisions. Women usually timed their ban on sexual relations with their periods of infertility while they were menstruating, and to the extent that their solidarity drew women together, these periods tended to occur in synchrony. The result was that every month with the onset of menstruation, sexual relations were ruptured in a collective, ritualistic way as the prelude to each successful hunting expedition. This ritual act was the means through which women motivated men not only to hunt but also to concentrate energies on bringing back the meat. Knight shows how this hypothesis sheds light on the roots of such cultural traditions as totemic rituals, incest and menstrual taboos, blood-sacrifice, and hunters’ atonement rites. Providing detailed ethnographic documentation, he also explains how Native American, Australian Aboriginal, and other magico-religious myths can be read as derivatives of the same symbolic logic.
While working on a project translating letters from sixteenth-century Prague, high school senior Nora Kane discovers her best friend murdered with her boyfriend the apparent killer and is caught up in a dangerous web of secret societies and shadowy conspirators, all searching for a mysterious ancient device purported to allow direct communication with God.
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market